"Dithiothreitol" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.
| Descriptor ID |
D004229
|
| MeSH Number(s) |
D02.033.800.196 D02.886.740.224 D09.853.196
|
| Concept/Terms |
Dithiothreitol- Dithiothreitol
- Cleland's Reagent
- Clelands Reagent
- Reagent, Cleland's
- Cleland Reagent
- Reagent, Cleland
|
Below are MeSH descriptors whose meaning is more general than "Dithiothreitol".
Below are MeSH descriptors whose meaning is more specific than "Dithiothreitol".
This graph shows the total number of publications written about "Dithiothreitol" by people in this website by year, and whether "Dithiothreitol" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Dithiothreitol" by people in Profiles.
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Israel BA, Kodali VK, Thorpe C. Going through the barrier: coupled disulfide exchange reactions promote efficient catalysis in quiescin sulfhydryl oxidase. J Biol Chem. 2014 Feb 21; 289(8):5274-84.
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Ramadan D, Rancy PC, Nagarkar RP, Schneider JP, Thorpe C. Arsenic(III) species inhibit oxidative protein folding in vitro. Biochemistry. 2009 Jan 20; 48(2):424-32.
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Motlekar N, Diamond SL, Napper AD. Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev Technol. 2008 Jun; 6(3):395-405.
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Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett. 2007 Sep 01; 17(17):4761-6.
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Wang W, Winther JR, Thorpe C. Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase. Biochemistry. 2007 Mar 20; 46(11):3246-54.
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Cline DJ, Redding SE, Brohawn SG, Psathas JN, Schneider JP, Thorpe C. New water-soluble phosphines as reductants of peptide and protein disulfide bonds: reactivity and membrane permeability. Biochemistry. 2004 Dec 07; 43(48):15195-203.
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Raje S, Glynn NM, Thorpe C. A continuous fluorescence assay for sulfhydryl oxidase. Anal Biochem. 2002 Aug 15; 307(2):266-72.
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Joseph SK, Boehning D, Bokkala S, Watkins R, Widjaja J. Biosynthesis of inositol trisphosphate receptors: selective association with the molecular chaperone calnexin. Biochem J. 1999 Aug 15; 342 ( Pt 1):153-61.
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Dupr? S, Fontana M, Pitari G, Cavallini D. In vitro reactions of hypotaurine. Adv Exp Med Biol. 1996; 403:3-8.
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Thakur ML, DeFulvio J, Richard MD, Park CH. Technetium-99m labeled monoclonal antibodies: evaluation of reducing agents. Int J Rad Appl Instrum B. 1991; 18(2):227-33.