"Genes, Lethal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
| Descriptor ID |
D005804
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| MeSH Number(s) |
G05.360.340.024.340.350
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genes, Lethal".
Below are MeSH descriptors whose meaning is more specific than "Genes, Lethal".
This graph shows the total number of publications written about "Genes, Lethal" by people in this website by year, and whether "Genes, Lethal" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
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Below are the most recent publications written about "Genes, Lethal" by people in Profiles.
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Samaan G, Yugo D, Rajagopalan S, Wall J, Donnell R, Goldowitz D, Gopalakrishnan R, Venkatachalam S. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Biochem Biophys Res Commun. 2010 Sep 10; 400(1):60-5.
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Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B. SCCRO promotes glioma formation and malignant progression in mice. Neoplasia. 2010 Jun; 12(6):476-84.
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Danielson KG, Siracusa LD, Donovan PJ, Iozzo RV. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Mamm Genome. 1999 Feb; 10(2):201-3.
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McMillan JR, McGrath JA, Pulkkinen L, Kon A, Burgeson RE, Ortonne JP, Meneguzzi G, Uitto J, Eady RA. Immunohistochemical analysis of the skin in junctional epidermolysis bullosa using laminin 5 chain specific antibodies is of limited value in predicting the underlying gene mutation. Br J Dermatol. 1997 Jun; 136(6):817-22.
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Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8919-23.
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Franks RR, Rencic A, Gordon J, Zoltick PW, Curtis M, Knobler RL, Khalili K. Formation of undifferentiated mesenteric tumors in transgenic mice expressing human neurotropic polymavirus early protein. Oncogene. 1996 Jun 20; 12(12):2573-8.
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Pavan WJ, Liddell RA, Wright A, Thibaudeau G, Matteson PG, McHugh KM, Siracusa LD. A high-resolution linkage map of the lethal spotting locus: a mouse model for Hirschsprung disease. Mamm Genome. 1995 Jan; 6(1):1-7.
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Fertala A, Westerhausen A, Morris G, Rooney JE, Prockop DJ. Two cysteine substitutions in procollagen I: a glycine replacement near the N-terminus of alpha 1(I) chain causes lethal osteogenesis imperfecta and a glycine replacement in the alpha 2(I) chain markedly destabilizes the triple helix. Biochem J. 1993 Jan 01; 289 ( Pt 1):195-9.
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Siracusa LD. Genomic organization and molecular genetics of the agouti locus in the mouse. Ann N Y Acad Sci. 1991 Dec 26; 642:419-30.
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Radice G, Lee JJ, Costantini F. H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Development. 1991 Mar; 111(3):801-11.