Genes, Lethal

"Genes, Lethal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.

Descriptor ID	D005804
MeSH Number(s)	G05.360.340.024.340.350
Concept/Terms	Genes, Lethal Genes, Lethal Gene, Lethal Lethal Gene Lethal Genes Alleles, Lethal Alleles, Lethal Allele, Lethal Lethal Allele Lethal Alleles

Below are MeSH descriptors whose meaning is more general than "Genes, Lethal".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Lethal [G05.360.340.024.340.350]

Below are MeSH descriptors whose meaning is more specific than "Genes, Lethal".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, Lethal" by people in this website by year, and whether "Genes, Lethal" was a major or minor topic of these publications.

Bar chart showing 14 publications over 10 distinct years, with a maximum of 3 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1997	0	1	1
1999	1	0	1
2004	0	1	1
2007	0	1	1
2010	1	1	2
2011	0	1	1
2012	1	2	3
2013	1	0	1
2020	0	1	1

Below are the most recent publications written about "Genes, Lethal" by people in Profiles.

Tripolszki K, Sasaki E, Hotakainen R, Kassim AH, Pereira C, Rolfs A, Bauer P, Reardon W, Bertoli-Avella AM. An X-linked syndrome with severe neurodevelopmental delay, hydrocephalus, and early lethality caused by a missense variation in the OTUD5 gene. Clin Genet. 2021 02; 99(2):303-308.

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Bull JJ, Joyce P, Gladstone E, Molineux IJ. Empirical complexities in the genetic foundations of lethal mutagenesis. Genetics. 2013 Oct; 195(2):541-52.

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Carbonell A, Mazo A, Serras F, Corominas M. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr. Mol Biol Cell. 2013 Feb; 24(3):361-72.

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Adair-Kirk TL, Griffin GL, Meyer MJ, Kelley DG, Miner JH, Keene DR, Marinkovich MP, Ruppert JM, Uitto J, Senior RM. Keratinocyte-targeted expression of human laminin ?2 rescues skin blistering and early lethality of laminin ?2 deficient mice. PLoS One. 2012; 7(9):e45546.

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Swope D, Li J, Muller EJ, Radice GL. Analysis of a Jup hypomorphic allele reveals a critical threshold for postnatal viability. Genesis. 2012 Oct; 50(10):717-27.

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Arakawa H, Bednar T, Wang M, Paul K, Mladenov E, Bencsik-Theilen AA, Iliakis G. Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells. Nucleic Acids Res. 2012 Mar; 40(6):2599-610.

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Samaan G, Yugo D, Rajagopalan S, Wall J, Donnell R, Goldowitz D, Gopalakrishnan R, Venkatachalam S. Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Biochem Biophys Res Commun. 2010 Sep 10; 400(1):60-5.

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Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B. SCCRO promotes glioma formation and malignant progression in mice. Neoplasia. 2010 Jun; 12(6):476-84.

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Astrof S, Crowley D, Hynes RO. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol. 2007 Nov 01; 311(1):11-24.

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Kiehart DP, Franke JD, Chee MK, Montague RA, Chen TL, Roote J, Ashburner M. Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. Genetics. 2004 Nov; 168(3):1337-52.

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