"Multigene Family" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
| Descriptor ID |
D005810
|
| MeSH Number(s) |
G05.360.340.024.340.645
|
| Concept/Terms |
Multigene Family- Multigene Family
- Families, Multigene
- Family, Multigene
- Multigene Families
Gene Clusters- Gene Clusters
- Cluster, Gene
- Clusters, Gene
- Gene Cluster
|
Below are MeSH descriptors whose meaning is more general than "Multigene Family".
Below are MeSH descriptors whose meaning is more specific than "Multigene Family".
This graph shows the total number of publications written about "Multigene Family" by people in this website by year, and whether "Multigene Family" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 0 | 2 | 2 |
| 1999 | 1 | 2 | 3 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 0 | 3 | 3 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
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Below are the most recent publications written about "Multigene Family" by people in Profiles.
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Bournazos S, Ravetch JV. Fc? receptor pathways during active and passive immunization. Immunol Rev. 2015 Nov; 268(1):88-103.
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Iozzo RV, Schaefer L. Proteoglycan form and function: A comprehensive nomenclature of proteoglycans. Matrix Biol. 2015 Mar; 42:11-55.
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Jin L, Lim M, Zhao S, Sano Y, Simone BA, Savage JE, Wickstrom E, Camphausen K, Pestell RG, Simone NL. The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster. Breast Cancer Res Treat. 2014 Jul; 146(1):41-50.
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Sharma V, He C, Sacca-Schaeffer J, Brzozowski E, Martin-Herranz DE, Mendelowitz Z, Fitzpatrick DA, O'Halloran DM. Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans. Genetics. 2013 Oct; 195(2):611-9.
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Zelle KM, Lu B, Pyfrom SC, Ben-Shahar Y. The genetic architecture of degenerin/epithelial sodium channels in Drosophila. G3 (Bethesda). 2013 Mar; 3(3):441-50.
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Kraus C, Rohde D, Weidenhammer C, Qiu G, Pleger ST, Voelkers M, Boerries M, Remppis A, Katus HA, Most P. S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy. J Mol Cell Cardiol. 2009 Oct; 47(4):445-55.
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Brock HW, Hodgson JW, Petruk S, Mazo A. Regulatory noncoding RNAs at Hox loci. Biochem Cell Biol. 2009 Feb; 87(1):27-34.
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Cho SH, Goenka S, Henttinen T, Gudapati P, Reinikainen A, Eischen CM, Lahesmaa R, Boothby M. PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells. Blood. 2009 Mar 12; 113(11):2416-25.
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Pratt CH, Vadigepalli R, Chakravarthula P, Gonye GE, Philp NJ, Grunwald GB. Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium. Mol Vis. 2008 Aug 04; 14:1414-28.
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Schaefer L, Iozzo RV. Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem. 2008 Aug 01; 283(31):21305-9.