Insulin

"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Descriptor ID	D007328
MeSH Number(s)	D06.472.699.587.200.500.625 D12.644.548.586.200.500.625
Concept/Terms	Insulin Insulin Insulin, Regular Regular Insulin Soluble Insulin Insulin, Soluble Insulin A Chain Insulin A Chain Sodium Insulin Sodium Insulin Insulin, Sodium Novolin Novolin Iletin Iletin Insulin B Chain Insulin B Chain Chain, Insulin B

Below are MeSH descriptors whose meaning is more general than "Insulin".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Pancreatic Hormones [D06.472.699.587]
Insulins [D06.472.699.587.200]
Proinsulin [D06.472.699.587.200.500]
Insulin [D06.472.699.587.200.500.625]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Hormones [D12.644.548]
Pancreatic Hormones [D12.644.548.586]
Insulins [D12.644.548.586.200]
Proinsulin [D12.644.548.586.200.500]
Insulin [D12.644.548.586.200.500.625]

Below are MeSH descriptors whose meaning is related to "Insulin".

Below are MeSH descriptors whose meaning is more specific than "Insulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Insulin" by people in this website by year, and whether "Insulin" was a major or minor topic of these publications.

Bar chart showing 182 publications over 30 distinct years, with a maximum of 13 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	4	4
1998	1	3	4
1999	3	4	7
2000	2	2	4
2001	2	1	3
2002	1	2	3
2003	1	4	5
2004	7	6	13
2005	2	3	5
2006	2	2	4
2007	0	3	3
2008	4	8	12
2009	1	4	5
2010	7	2	9
2011	2	10	12
2012	7	3	10
2013	4	8	12
2014	1	6	7
2015	1	4	5
2016	2	7	9
2017	5	4	9
2018	3	2	5
2019	4	6	10
2020	2	3	5
2021	2	3	5
2022	1	2	3
2023	2	4	6
2024	0	1	1
2025	1	0	1

Below are the most recent publications written about "Insulin" by people in Profiles.

LaRovere KL, Asaro LA, Coughlin-Wells K, Nadkarni VM, Agus MSD. Blood Glucose Range for Hyperglycemic PICU Children With Primary Neurologic Diagnoses: Analysis of the Heart and Lung Failure-Pediatric Insulin Titration (HALF-PINT) Trial. Pediatr Crit Care Med. 2025 Apr 01; 26(4):e432-e446.

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Orbell SL, Codario RA, Zupa MF, Estock JL. Severe Insulin Pump-Related Adverse Events: Potential Root Causes and Impact of the COVID-19 Pandemic. J Diabetes Sci Technol. 2025 11; 19(6):1614-1623.

View in: PubMed
Hoover Z, Lynn M, Zhaliazka K, Holman AP, Dou T, Kurouski D. Long-Chain Polyunsaturated Fatty Acids Accelerate the Rate of Insulin Aggregation and Enhance Toxicity of Insulin Aggregates. ACS Chem Neurosci. 2024 01 03; 15(1):147-154.

View in: PubMed
Preston WA, Pace DJ, Altshuler PJ, Yi M, Kittle HD, Vincent SA, Andreoni KA, Frank AM, Glorioso JM, Ramirez CG, Maley WR, Shah AP, Bodzin AS. A propensity score matched analysis of liver transplantation outcomes in the setting of preservation solution shortage. Am J Transplant. 2024 Apr; 24(4):619-630.

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Estock JL, Codario RA, Zupa MF, Keddem S, Rodriguez KL. Insulin Pump Alarms During Adverse Events: A Qualitative Descriptive Study. J Diabetes Sci Technol. 2025 05; 19(3):739-748.

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Sideri Gugger A, Dimino C, Panigrahi SK, Mayer L, Smiley RM, Korner J, Wardlaw SL. Defining Predictors of Weight Loss Response to Lorcaserin. J Clin Endocrinol Metab. 2023 08 18; 108(9):2262-2271.

View in: PubMed
Zinter MS, Markovic D, Asaro LA, Nadkarni VM, McQuillen PS, Sinha P, Matthay MA, Jeschke MG, Agus MSD, Sapru A. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. Am J Respir Crit Care Med. 2023 04 01; 207(7):945-949.

View in: PubMed
Estock JL, Codario RA, Keddem S, Zupa MF, Rodriguez KL, DiNardo MM. Insulin Pump-Associated Adverse Events: A Qualitative Descriptive Study of Clinical Consequences and Potential Root Causes. Diabetes Technol Ther. 2023 05; 25(5):343-355.

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Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL. G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. J Biol Chem. 2022 10; 298(10):102421.

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Sholevar C, Torjani A, Kavanagh TR, Yudkoff C, Xiao K, Swaminathan V, Rshaidat H, Bowne WB, Krampitz GW, Nevler A, Yeo CJ, Lavu H. Euglycemic diabetic ketoacidosis (EDKA) after pancreaticoduodenectomy: An under-recognized metabolic abnormality with outcome implications. Surgery. 2023 04; 173(4):888-893.

View in: PubMed

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