"Proinsulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
| Descriptor ID |
D011384
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| MeSH Number(s) |
D06.472.699.587.200.500 D12.644.548.586.200.500 D12.776.811.706
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proinsulin".
Below are MeSH descriptors whose meaning is more specific than "Proinsulin".
This graph shows the total number of publications written about "Proinsulin" by people in this website by year, and whether "Proinsulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Proinsulin" by people in Profiles.
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Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL. G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. J Biol Chem. 2022 10; 298(10):102421.
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Steyaert W, Varney MJ, Benovic JL, Creemers J, Speeckaert MM, Coucke PJ, Delanghe JR. Hypergastrinemia, a clue leading to the identification of an atypical form of diabetes mellitus type 2. Clin Chim Acta. 2022 Jul 01; 532:79-83.
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Belfiore A, Malaguarnera R, Vella V, Lawrence MC, Sciacca L, Frasca F, Morrione A, Vigneri R. Insulin Receptor Isoforms in Physiology and Disease: An Updated View. Endocr Rev. 2017 10 01; 38(5):379-431.
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Morcavallo A, Buraschi S, Xu SQ, Belfiore A, Schaefer L, Iozzo RV, Morrione A. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol. 2014 Apr; 35:82-90.
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Zhang H, Legro RS, Zhang J, Zhang L, Chen X, Huang H, Casson PR, Schlaff WD, Diamond MP, Krawetz SA, Coutifaris C, Brzyski RG, Christman GM, Santoro N, Eisenberg E. Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Hum Reprod. 2010 Oct; 25(10):2612-21.
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Stickle DF, Reynolds MA, Morris MD, Quon MJ. Dynamic changes in plasma proinsulin/insulin ratio during insulin secretion influence correlation between radioimmunoassay (RIA) and IMX measurements of insulin. Clin Chim Acta. 1999 Jun 15; 284(1):1-13.
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Kapp JA, Strayer DS. H-2 linked Ir gene control of antibody responses to porcine insulin. I. Development of insulin-specific antibodies in some but not all nonresponder strains injected with proinsulin. J Immunol. 1978 Sep; 121(3):978-82.