C-Peptide

"C-Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.

Descriptor ID	D002096
MeSH Number(s)	D06.472.699.587.200.500.250 D12.644.548.586.200.500.250
Concept/Terms	C-Peptide C-Peptide C Peptide Connecting Peptide Proinsulin C-Peptide Proinsulin C Peptide C-Peptide, Proinsulin C Peptide, Proinsulin

Below are MeSH descriptors whose meaning is more general than "C-Peptide".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Pancreatic Hormones [D06.472.699.587]
Insulins [D06.472.699.587.200]
Proinsulin [D06.472.699.587.200.500]
C-Peptide [D06.472.699.587.200.500.250]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Hormones [D12.644.548]
Pancreatic Hormones [D12.644.548.586]
Insulins [D12.644.548.586.200]
Proinsulin [D12.644.548.586.200.500]
C-Peptide [D12.644.548.586.200.500.250]

Below are MeSH descriptors whose meaning is related to "C-Peptide".

Below are MeSH descriptors whose meaning is more specific than "C-Peptide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "C-Peptide" by people in this website by year, and whether "C-Peptide" was a major or minor topic of these publications.

Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 1999 and 2005 and 2006 and 2008 and 2009 and 2010 and 2012 and 2016 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2005	1	0	1
2006	0	1	1
2008	0	1	1
2009	1	0	1
2010	1	0	1
2012	0	1	1
2016	0	1	1
2020	0	1	1

Below are the most recent publications written about "C-Peptide" by people in Profiles.

Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Pollak MN, Nixon AB, Mullen BC, O'Neil BH, Shaw JE, Polite BN, Benson AB, Atkins JN, Goldberg RM, Brown JC, O'Reilly EM, Mayer RJ, Blanke CD, Fuchs CS, Meyerhardt JA. IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405. JNCI Cancer Spectr. 2021 02; 5(1).

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Hansen M, Scheltema MJ, Sonne DP, Hansen JS, Sperling M, Rehfeld JF, Holst JJ, Vilsb?ll T, Knop FK. Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon-like peptide-1 secretion. Diabetes Obes Metab. 2016 06; 18(6):571-80.

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Wouters EF, Bredenbr?ker D, Teichmann P, Brose M, Rabe KF, Fabbri LM, G?ke B. Effect of the phosphodiesterase 4 inhibitor roflumilast on glucose metabolism in patients with treatment-naive, newly diagnosed type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012 Sep; 97(9):E1720-5.

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Fasano CJ, Rowden AK, O'Malley GF, Aguilera E, Heard K. Quantitative insulin and C-peptide levels among ED patients with sulfonylurea-induced hypoglycemia-a prospective case series. Am J Emerg Med. 2010 Oct; 28(8):952-5.

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Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ. C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience. 2009 Mar 17; 159(2):492-500.

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Fuchs CS, Goldberg RM, Sargent DJ, Meyerhardt JA, Wolpin BM, Green EM, Pitot HC, Pollak M. Plasma insulin-like growth factors, insulin-like binding protein-3, and outcome in metastatic colorectal cancer: results from intergroup trial N9741. Clin Cancer Res. 2008 Dec 15; 14(24):8263-9.

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Noguchi H, Iwanaga Y, Okitsu T, Nagata H, Yonekawa Y, Matsumoto S. Evaluation of islet transplantation from non-heart beating donors. Am J Transplant. 2006 Oct; 6(10):2476-82.

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Meyerhardt JA, Sloan JA, Sargent DJ, Goldberg RM, Pollak M, Morton RF, Ramanathan RK, Williamson SK, Findlay BP, Fuchs CS. Associations between plasma insulin-like growth factor proteins and C-peptide and quality of life in patients with metastatic colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2005 Jun; 14(6):1402-10.

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Stickle DF, McNeil SE. Evaluation of use of singleton measurements of C-peptide by RIA. Clin Chim Acta. 1999 May; 283(1-2):195-200.

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Akinbi HT, Gerdes JS. Macrosomic infants of nondiabetic mothers and elevated C-peptide levels in cord blood. J Pediatr. 1995 Sep; 127(3):481-4.

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