NAD

"NAD" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Descriptor ID	D009243
MeSH Number(s)	D03.633.100.759.646.138.694 D08.211.589 D13.695.667.138.694 D13.695.827.068.694
Concept/Terms	NAD NAD Dihydronicotinamide Adenine Dinucleotide Adenine Dinucleotide, Dihydronicotinamide Dinucleotide, Dihydronicotinamide Adenine Diphosphopyridine Nucleotide Nucleotide, Diphosphopyridine Nadide Nicotinamide-Adenine Dinucleotide Dinucleotide, Nicotinamide-Adenine Nicotinamide Adenine Dinucleotide Coenzyme I DPN NADH NADH

Below are MeSH descriptors whose meaning is more general than "NAD".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Purines [D03.633.100.759]
Purine Nucleotides [D03.633.100.759.646]
Adenine Nucleotides [D03.633.100.759.646.138]
NAD [D03.633.100.759.646.138.694]
Enzymes and Coenzymes [D08]
Coenzymes [D08.211]
NAD [D08.211.589]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Purine Nucleotides [D13.695.667]
Adenine Nucleotides [D13.695.667.138]
NAD [D13.695.667.138.694]
Ribonucleotides [D13.695.827]
Adenine Nucleotides [D13.695.827.068]
NAD [D13.695.827.068.694]

Below are MeSH descriptors whose meaning is more specific than "NAD".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NAD" by people in this website by year, and whether "NAD" was a major or minor topic of these publications.

Bar chart showing 41 publications over 22 distinct years, with a maximum of 5 publications in 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1998	0	1	1
1999	0	1	1
2001	0	1	1
2002	0	1	1
2004	1	0	1
2005	1	2	3
2006	1	1	2
2007	1	0	1
2009	1	0	1
2010	0	1	1
2011	0	2	2
2013	0	1	1
2014	2	0	2
2015	2	1	3
2016	0	4	4
2018	1	1	2
2019	1	1	2
2020	0	1	1
2022	1	3	4
2023	0	1	1
2024	3	2	5

Below are the most recent publications written about "NAD" by people in Profiles.

Langelier MF, Mirhasan M, Gilbert K, Sverzhinksy A, Furtos A, Pascal JM. PARP enzyme de novo synthesis of protein-free poly(ADP-ribose). Mol Cell. 2024 Dec 19; 84(24):4758-4773.e6.

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Sekiya M, Sakakibara Y, Hirota Y, Ito N, Chikamatsu S, Takei K, Nishijima R, Iijima KM. Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding A? plaques in a mouse model of Alzheimer's disease. Neurobiol Dis. 2024 11; 202:106694.

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Su SH, Mitani Y, Li T, Sachdeva U, Flashner S, Klein-Szanto A, Dunbar KJ, Abrams J, Nakagawa H, Gabre J. Lactate Suppresses Growth of Esophageal Adenocarcinoma Patient-Derived Organoids through Alterations in Tumor NADH/NAD+ Redox State. Biomolecules. 2024 09 22; 14(9).

View in: PubMed
Sorrells JE, Park J, Aksamitiene E, Marjanovic M, Martin EM, Chaney EJ, Higham AM, Cradock KA, Liu ZG, Boppart SA. Label-free nonlinear optical signatures of extracellular vesicles in liquid and tissue biopsies of human breast cancer. Sci Rep. 2024 03 06; 14(1):5528.

View in: PubMed
DeBartolo D, Arnold FJ, Liu Y, Molotsky E, Tang HY, Merry DE. Differentially disrupted spinal cord and muscle energy metabolism in spinal and bulbar muscular atrophy. JCI Insight. 2024 03 05; 9(7).

View in: PubMed
Frigon L, Pascal JM. Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res. 2023 12 11; 51(22):12492-12507.

View in: PubMed
Arnold MR, Langelier MF, Gartrell J, Kirby IT, Sanderson DJ, Bejan DS, ?ileikyte J, Sundalam SK, Nagarajan S, Marimuthu P, Duell AK, Shelat AA, Pascal JM, Cohen MS. Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors. Cell Chem Biol. 2022 12 15; 29(12):1694-1708.e10.

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Rouleau-Turcotte ?, Krastev DB, Pettitt SJ, Lord CJ, Pascal JM. Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol Cell. 2022 08 18; 82(16):2939-2951.e5.

View in: PubMed
Kotova EY, Hsieh FK, Chang HW, Maluchenko NV, Langelier MF, Pascal JM, Luse DS, Feofanov AV, Studitsky VM. Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro. Int J Mol Sci. 2022 Jun 26; 23(13).

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Dahle ML, Papoutsakis ET, Antoniewicz MR. 13C-metabolic flux analysis of Clostridium ljungdahlii illuminates its core metabolism under mixotrophic culture conditions. Metab Eng. 2022 07; 72:161-170.

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