"Phenobarbital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
| Descriptor ID |
D010634
|
| MeSH Number(s) |
D03.383.742.698.253.650
|
| Concept/Terms |
Phenobarbital- Phenobarbital
- Phenylbarbital
- Phenylethylbarbituric Acid
- Acid, Phenylethylbarbituric
- Phenemal
- Phenobarbitone
Phenobarbital Sodium- Phenobarbital Sodium
- Sodium, Phenobarbital
- Phenobarbital, Monosodium Salt
- Monosodium Salt Phenobarbital
|
Below are MeSH descriptors whose meaning is more general than "Phenobarbital".
Below are MeSH descriptors whose meaning is more specific than "Phenobarbital".
This graph shows the total number of publications written about "Phenobarbital" by people in this website by year, and whether "Phenobarbital" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phenobarbital" by people in Profiles.
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Anbalagan S, Anderson V, Favara MT, Stark D, Carola D, Solarin K, Adeniyi-Jones S, Kraft WK, Aghai ZH. Buprenorphine vs. morphine: impact on neonatal opioid withdrawal syndrome (NOWS) outcomes in a single center retrospective study. J Perinatol. 2025 Apr; 45(4):473-479.
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Friedman D, Zubair N, Favara MT, Lafferty M, Carola D, Adeniyi-Jones S, Solarin K, Aghai ZH. Do small for gestational age infants have less severe neonatal abstinence syndrome? J Neonatal Perinatal Med. 2022; 15(4):753-758.
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Smith J, Lafferty M, Boelig RC, Carola D, Adeniyi-Jones S, Kraft WK, Greenspan JS, Aghai ZH. Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome? Am J Perinatol. 2022 07; 39(10):1138-1144.
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Kraft WK, Adeniyi-Jones SC, Chervoneva I, Greenspan JS, Abatemarco D, Kaltenbach K, Ehrlich ME. Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome. N Engl J Med. 2017 06 15; 376(24):2341-2348.
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Maitre NL, Smolinsky C, Slaughter JC, Stark AR. Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. J Perinatol. 2013 Nov; 33(11):841-6.
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Kraft WK, Dysart K, Greenspan JS, Gibson E, Kaltenbach K, Ehrlich ME. Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome. Addiction. 2011 Mar; 106(3):574-80.
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Kyle ME, Nakae D, Serroni A, Farber JL. 1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals. Mol Pharmacol. 1988 Oct; 34(4):584-9.
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Rosenwasser RH, Buchheit WA, Truex RC. Management of subarachnoid hemorrhage. Pa Med. 1984 Dec; 87(12):72, 74, 76.
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Israel Y, Carmichael FJ, Macdonald JA. Effects of ethanol on electrolyte metabolism and neurotransmitter release in the CNS. Adv Exp Med Biol. 1975; 59:55-64.
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Hesbacher PT, Rickels K, Gordon PE, Gray B, Meckelnburg R, Weise CC, Vandervort WJ. Setting, patient, and doctor effects on drug response in neurotic patients. I. Differential attrition, dosage deviation, and side reaction responses to treatment. Psychopharmacologia. 1970; 18(2):180-208.