Platelet Activating Factor
"Platelet Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
| Descriptor ID |
D010972
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| MeSH Number(s) |
D02.033.100.291.211.500 D02.092.063.291.211.500 D02.092.877.883.333.710 D02.675.276.232.710 D10.570.755.375.760.400.985.910 D23.119.865 D23.469.050.600
|
| Concept/Terms |
Platelet Activating Factor- Platelet Activating Factor
- Factor, Platelet Activating
- Phosphorylcholine, Acetyl Glyceryl Ether
- Platelet Aggregating Factor
- Aggregating Factor, Platelet
- Platelet Aggregation Enhancing Factor
- AGEPC
- Thrombocyte Aggregating Activity
- 1-Alkyl-2-acetyl-sn-glycerophosphocholine
- 1 Alkyl 2 acetyl sn glycerophosphocholine
- Acetyl Glyceryl Ether Phosphorylcholine
- PAF-Acether
- PAF Acether
- Platelet-Activating Substance
- Platelet Activating Substance
|
Below are MeSH descriptors whose meaning is more general than "Platelet Activating Factor".
Below are MeSH descriptors whose meaning is more specific than "Platelet Activating Factor".
This graph shows the total number of publications written about "Platelet Activating Factor" by people in this website by year, and whether "Platelet Activating Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Platelet Activating Factor" by people in Profiles.
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Harleton E, Besana A, Comas GM, Danilo P, Rosen TS, Argenziano M, Rosen MR, Robinson RB, Feinmark SJ. Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). J Biol Chem. 2013 Jan 25; 288(4):2829-38.
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Samanta U, Bahnson BJ. Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. J Biol Chem. 2008 Nov 14; 283(46):31617-24.
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Pan YH, Yu BZ, Berg OG, Jain MK, Bahnson BJ. Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. Biochemistry. 2002 Dec 17; 41(50):14790-800.
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Schwartz JD, Shamamian P, Schwartz DS, Grossi EA, Jacobs CE, Steiner F, Minneci PC, Baumann FG, Colvin SB, Galloway AC. Cardiopulmonary bypass primes polymorphonuclear leukocytes. J Surg Res. 1998 Mar; 75(2):177-82.
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Kim CJ, Kane GC, Zangrilli JG, Cho SK, Koh YY, Peters SP. Eosinophils recruited to the lung by segmental antigen challenge show a reduced chemotactic response to leukotriene B4. Prostaglandins. 1994 May; 47(5):393-403.
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Pi F, Hotter G, Closa D, Rosell?-Catafau J, Bulbena O, Badosa F, Morris M, Fern?ndez-Cruz L, Gelpi E. Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. Transplantation. 1994 Jan; 57(1):12-7.
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Cipolle MD, Pasquale MD, Cerra FB. Secondary organ dysfunction. From clinical perspectives to molecular mediators. Crit Care Clin. 1993 Apr; 9(2):261-98.
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Caplan MS, Hsueh W, Sun XM, Gidding SS, Hageman JR. Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. Am Rev Respir Dis. 1990 Dec; 142(6 Pt 1):1258-62.
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Chung KF, Cuss FM, Barnes PJ. Platelet activating factor: effects on bronchomotor tone and bronchial responsiveness in human beings. Allergy Proc. 1989 Sep-Oct; 10(5):333-7.
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Cuss FM, Dixon CM, Barnes PJ. Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. Lancet. 1986 Jul 26; 2(8500):189-92.