"Platelet Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
| Descriptor ID |
D010978
|
| MeSH Number(s) |
D12.644.276.374.200.120.900 D12.776.124.125.720 D12.776.467.374.200.120.900 D23.119.940 D23.125.300.120.900 D23.469.200.120.900 D23.529.374.200.120.900
|
| Concept/Terms |
Platelet Factor 4- Platelet Factor 4
- Chemokine CXCL4
- CXCL4, Chemokine
- PF4 (Platelet Factor 4)
- gamma-Thromboglobulin
- gamma Thromboglobulin
- Heparin Neutralizing Protein
- Antiheparin Factor
- CXCL4 Chemokine
- Chemokine, CXCL4
|
Below are MeSH descriptors whose meaning is more general than "Platelet Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Platelet Factor 4".
This graph shows the total number of publications written about "Platelet Factor 4" by people in this website by year, and whether "Platelet Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Platelet Factor 4" by people in Profiles.
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Beck TN, Boumber YA, Aggarwal C, Pei J, Thrash-Bingham C, Fittipaldi P, Vlasenkova R, Rao C, Borghaei H, Cristofanilli M, Mehra R, Serebriiskii I, Alpaugh RK. Circulating tumor cell and cell-free RNA capture and expression analysis identify platelet-associated genes in metastatic lung cancer. BMC Cancer. 2019 Jun 19; 19(1):603.
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Naik UP. Bacteria exploit platelets. Blood. 2014 May 15; 123(20):3067-8.
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De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. J Thromb Haemost. 2007 Mar; 5(3):551-9.
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Cui Z, Reilly MP, Surrey S, Schwartz E, McKenzie SE. -245 bp of 5'-flanking region from the human platelet factor 4 gene is sufficient to drive megakaryocyte-specific expression in vivo. Blood. 1998 Apr 01; 91(7):2326-33.
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Eisman R, Surrey S, Ramachandran B, Schwartz E, Poncz M. Structural and functional comparison of the genes for human platelet factor 4 and PF4alt. Blood. 1990 Jul 15; 76(2):336-44.
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Park KS, Rifat S, Eck H, Adachi K, Surrey S, Poncz M. Biologic and biochemic properties of recombinant platelet factor 4 demonstrate identity with the native protein. Blood. 1990 Mar 15; 75(6):1290-5.
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Guzzo C, Weiner M, Rappaport E, LaRocco P, Surrey S, Poncz M, Schwartz E. An Eco R1 polymorphism of a human platelet factor 4 (PF4) gene. Nucleic Acids Res. 1987 Jan 12; 15(1):380.
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Poncz M, Surrey S, LaRocco P, Weiss MJ, Rappaport EF, Conway TM, Schwartz E. Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line. Blood. 1987 Jan; 69(1):219-23.
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Landolfi R, Storti S, Sacco F, Scribano D, Cudillo L, Leone G. Platelet activation in patients with benign and malignant ovarian diseases. Tumori. 1984 Oct 31; 70(5):459-62.
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Addonizio VP, Macarak EJ, Niewiarowski S, Colman RW, Edmunds LH. Preservation of human platelets with prostaglandin E1 during in vitro simulation of cardiopulmonary bypass. Circ Res. 1979 Mar; 44(3):350-7.