"SRS-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
| Descriptor ID |
D013189
|
| MeSH Number(s) |
D10.251.355.255.100.450.855 D10.251.355.310.166.887.855 D23.469.050.175.450.725
|
| Concept/Terms |
SRS-A- SRS-A
- Slow Reacting Substance of Anaphylaxis
|
Below are MeSH descriptors whose meaning is more general than "SRS-A".
Below are MeSH descriptors whose meaning is more specific than "SRS-A".
This graph shows the total number of publications written about "SRS-A" by people in this website by year, and whether "SRS-A" was a major or minor topic of these publications.
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Below are the most recent publications written about "SRS-A" by people in Profiles.
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Landolfi R, Ciabattoni G, Patrignani P, Castellana MA, Pogliani E, Bizzi B, Patrono C. Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo. Blood. 1992 Oct 15; 80(8):1965-71.
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Ortega E, Hazan B, Zor U, Pecht I. Mast cell stimulation by monoclonal antibodies specific for the Fc epsilon receptor yields distinct responses of arachidonic acid and leukotriene C4 secretion. Eur J Immunol. 1989 Dec; 19(12):2251-6.
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Cooper DR, Kelliher GJ, Kowey PR. Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat. Am Heart J. 1988 Nov; 116(5 Pt 1):1194-200.
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Roth DM, Reibel DK, Lefer AM. Altered coronary vascular responsiveness to leukotrienes in alloxan-diabetic rats. Circ Res. 1984 Apr; 54(4):388-95.
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Janoff A. Mediators of tissue damage in human polymorphonuclear neutrophils. Ser Haematol. 1970; 3(1):96-130.