"Leukotrienes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
| Descriptor ID |
D015289
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| MeSH Number(s) |
D10.251.355.255.100.450 D10.251.355.310.166.887 D23.469.050.175.450
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leukotrienes".
Below are MeSH descriptors whose meaning is more specific than "Leukotrienes".
This graph shows the total number of publications written about "Leukotrienes" by people in this website by year, and whether "Leukotrienes" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Leukotrienes" by people in Profiles.
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Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 12 04; 57(48):6726-6734.
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Ball AK, Beilstein K, Wittmann S, S?r?n D, Saul MJ, Schn?tgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, H?fner AK, Steinhilber D. Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LO?13, 5-LO?4 and 5-LOp12. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May; 1862(5):561-571.
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Deshpande DA, Pascual RM, Wang SW, Eckman DM, Riemer EC, Funk CD, Penn RB. PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation. FASEB J. 2007 Aug; 21(10):2335-42.
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Jian W, Lee SH, Arora JS, Silva Elipe MV, Blair IA. Unexpected formation of etheno-2'-deoxyguanosine adducts from 5(S)-hydroperoxyeicosatetraenoic acid: evidence for a bis-hydroperoxide intermediate. Chem Res Toxicol. 2005 Mar; 18(3):599-610.
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Allen-Ramey FC, Duong PT, Goodman DC, Sajjan SG, Nelsen LM, Santanello NC, Markson LE. Treatment effectiveness of inhaled corticosteroids and leukotriene modifiers for patients with asthma: an analysis from managed care data. Allergy Asthma Proc. 2003 Jan-Feb; 24(1):43-51.
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Gawchik SM, Saccar CL. Role of antileukotriene agents in asthma therapy. J Am Osteopath Assoc. 2000 Jan; 100(1):32, 37-43.
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Kane GC, Tollino M, Pollice M, Kim CJ, Cohn J, Murray JJ, Dworski R, Sheller J, Fish JE, Peters SP. Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. Prostaglandins. 1995 Jul; 50(1):1-18.
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Patrono C, Ciabattoni G, Patrignani P, Rocca B, Landolfi R. Eicosanoid biosynthesis and metabolism in myeloproliferative disorders. Ann N Y Acad Sci. 1994 Nov 15; 744:229-36.