"COP9 Signalosome Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
| Descriptor ID |
D000075686
|
| MeSH Number(s) |
D05.500.139 D08.811.037.750.250 D08.811.277.656.300.887.375
|
| Concept/Terms |
COP9 Signalosome Complex- COP9 Signalosome Complex
- Signalosome Complex, COP9
- Constitutive Photomorphogenesis 9 Signalsome
- COP9 Signalsome
- Signalsome, COP9
- Constitutive Photomorphogenesis 9 Signalosome
- COP9 Signalosome (CSN)
|
Below are MeSH descriptors whose meaning is more general than "COP9 Signalosome Complex".
Below are MeSH descriptors whose meaning is more specific than "COP9 Signalosome Complex".
This graph shows the total number of publications written about "COP9 Signalosome Complex" by people in this website by year, and whether "COP9 Signalosome Complex" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "COP9 Signalosome Complex" by people in Profiles.
-
Omede A, Zi M, Prehar S, Maqsood A, Stafford N, Mamas M, Cartwright E, Oceandy D. The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochem Biophys Res Commun. 2016 Oct 28; 479(4):708-714.
-
Kinoshita SM, Krutzik PO, Nolan GP. COP9 signalosome component JAB1/CSN5 is necessary for T cell signaling through LFA-1 and HIV-1 replication. PLoS One. 2012; 7(7):e41725.
-
Knowles A, Koh K, Wu JT, Chien CT, Chamovitz DA, Blau J. The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci. 2009 Jan 28; 29(4):1152-62.
-
Esteva FJ, Sahin AA, Rassidakis GZ, Yuan LX, Smith TL, Yang Y, Gilcrease MZ, Cristofanilli M, Nahta R, Pusztai L, Claret FX. Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer. Clin Cancer Res. 2003 Nov 15; 9(15):5652-9.
-
Perez OD, Mitchell D, Jager GC, South S, Murriel C, McBride J, Herzenberg LA, Kinoshita S, Nolan GP. Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Nat Immunol. 2003 Nov; 4(11):1083-92.