"Lumican" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.
| Descriptor ID |
D000071234
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| MeSH Number(s) |
D09.698.735.700.875 D12.776.395.650.875.750 D12.776.860.300.806.875
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lumican".
Below are MeSH descriptors whose meaning is more specific than "Lumican".
This graph shows the total number of publications written about "Lumican" by people in this website by year, and whether "Lumican" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lumican" by people in Profiles.
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Colon-Caraballo M, Lee N, Nallasamy S, Myers K, Hudson D, Iozzo RV, Mahendroo M. Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy. Matrix Biol. 2022 01; 105:53-71.
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Frey H, Schroeder N, Manon-Jensen T, Iozzo RV, Schaefer L. Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J. 2013 May; 280(10):2165-79.
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Schaefer L. Small leucine-rich proteoglycans in kidney disease. J Am Soc Nephrol. 2011 Jul; 22(7):1200-7.
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Sanches JC, Jones CJ, Aplin JD, Iozzo RV, Zorn TM, Oliveira SF. Collagen fibril organization in the pregnant endometrium of decorin-deficient mice. J Anat. 2010 Jan; 216(1):144-55.
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Chakravarti S, Zhang G, Chervoneva I, Roberts L, Birk DE. Collagen fibril assembly during postnatal development and dysfunctional regulation in the lumican-deficient murine cornea. Dev Dyn. 2006 Sep; 235(9):2493-506.
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Chakravarti S, Paul J, Roberts L, Chervoneva I, Oldberg A, Birk DE. Ocular and scleral alterations in gene-targeted lumican-fibromodulin double-null mice. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2422-32.
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Ezura Y, Chakravarti S, Oldberg A, Chervoneva I, Birk DE. Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons. J Cell Biol. 2000 Nov 13; 151(4):779-88.
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Danielson KG, Siracusa LD, Donovan PJ, Iozzo RV. Decorin, epiphycan, and lumican genes are closely linked on murine Chromosome 10 and are deleted in lethal steel mutants. Mamm Genome. 1999 Feb; 10(2):201-3.
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Iozzo RV. Proteoglycans: structure, function, and role in neoplasia. Lab Invest. 1985 Oct; 53(4):373-96.