"Beclin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
| Descriptor ID |
D000071186
|
| MeSH Number(s) |
D12.644.360.075.335 D12.776.094.500 D12.776.476.075.335
|
| Concept/Terms |
Beclin-1- Beclin-1
- Beclin 1
- Beclin-1 Protein
- Beclin 1 Protein
- GT197 Protein
- ATG-6 Protein
- ATG 6 Protein
- Coiled-coil Myosin-like Bcl2-interacting Protein
- Coiled coil Myosin like Bcl2 interacting Protein
- Beclin1
- ATG6 Protein
|
Below are MeSH descriptors whose meaning is more general than "Beclin-1".
Below are MeSH descriptors whose meaning is more specific than "Beclin-1".
This graph shows the total number of publications written about "Beclin-1" by people in this website by year, and whether "Beclin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Beclin-1" by people in Profiles.
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McAlinden KD, Deshpande DA, Ghavami S, Xenaki D, Sohal SS, Oliver BG, Haghi M, Sharma P. Autophagy Activation in Asthma Airways Remodeling. Am J Respir Cell Mol Biol. 2019 05; 60(5):541-553.
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Torres A, Gubbiotti MA, Iozzo RV. Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem. 2017 03 24; 292(12):5055-5069.
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Goyal A, Gubbiotti MA, Chery DR, Han L, Iozzo RV. Endorepellin-evoked Autophagy Contributes to Angiostasis. J Biol Chem. 2016 09 09; 291(37):19245-56.
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Poluzzi C, Casulli J, Goyal A, Mercer TJ, Neill T, Iozzo RV. Endorepellin evokes autophagy in endothelial cells. J Biol Chem. 2014 Jun 06; 289(23):16114-28.
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Goyal A, Neill T, Owens RT, Schaefer L, Iozzo RV. Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells. Matrix Biol. 2014 Feb; 34:46-54.
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Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens RT, Schaefer L, Torres A, Iozzo RV. Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2582-91.
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Liu Y, Schiff M, Czymmek K, Tall?czy Z, Levine B, Dinesh-Kumar SP. Autophagy regulates programmed cell death during the plant innate immune response. Cell. 2005 May 20; 121(4):567-577.