Ion Channel Gating

"Ion Channel Gating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.

Descriptor ID	D015640
MeSH Number(s)	G02.111.820.400 G04.835.400 G07.265.625
Concept/Terms	Ion Channel Gating Ion Channel Gating Gating, Ion Channel Gatings, Ion Channel Ion Channel Gatings

Below are MeSH descriptors whose meaning is more general than "Ion Channel Gating".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
Ion Channel Gating [G02.111.820.400]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
Ion Channel Gating [G04.835.400]
Physiological Phenomena [G07]
Electrophysiological Phenomena [G07.265]
Ion Channel Gating [G07.265.625]

Below are MeSH descriptors whose meaning is more specific than "Ion Channel Gating".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ion Channel Gating" by people in this website by year, and whether "Ion Channel Gating" was a major or minor topic of these publications.

Bar chart showing 90 publications over 24 distinct years, with a maximum of 6 publications in 2002 and 2006 and 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	3	4
1997	2	2	4
1998	2	1	3
1999	2	1	3
2000	1	3	4
2001	1	2	3
2002	5	1	6
2003	1	3	4
2004	1	1	2
2005	1	3	4
2006	2	4	6
2007	2	1	3
2008	4	2	6
2009	2	3	5
2010	2	3	5
2011	4	1	5
2012	3	1	4
2013	2	2	4
2014	1	2	3
2015	0	1	1
2016	1	4	5
2017	2	1	3
2018	1	1	2
2022	1	0	1

Below are the most recent publications written about "Ion Channel Gating" by people in Profiles.

Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, D?rr KL. Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nat Commun. 2022 07 15; 13(1):4087.

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Cheng L, Al-Owais M, Covarrubias ML, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo NA. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. J Biol Chem. 2018 07 13; 293(28):11022-11032.

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Yang E, Zhi L, Liang Q, Covarrubias M. Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics. Methods Enzymol. 2018; 602:339-368.

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Wu M, White HV, Boehm BA, Meriney CJ, Kerrigan K, Frasso M, Liang M, Gotway EM, Wilcox MR, Johnson JW, Wipf P, Meriney SD. New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease. Neuropharmacology. 2018 03 15; 131:176-189.

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Woll KA, Peng W, Liang Q, Zhi L, Jacobs JA, Maciunas L, Bhanu N, Garcia BA, Covarrubias M, Loll PJ, Dailey WP, Eckenhoff RG. Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel Modulation. ACS Chem Biol. 2017 05 19; 12(5):1353-1362.

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Dong Z, Shanmughapriya S, Tomar D, Siddiqui N, Lynch S, Nemani N, Breves SL, Zhang X, Tripathi A, Palaniappan P, Riitano MF, Worth AM, Seelam A, Carvalho E, Subbiah R, Ja?a F, Soboloff J, Peng Y, Cheung JY, Joseph SK, Caplan J, Rajan S, Stathopulos PB, Madesh M. Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity. Mol Cell. 2017 Mar 16; 65(6):1014-1028.e7.

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Bon E, Driffort V, Gradek F, Martinez-Caceres C, Anchelin M, Pelegrin P, Cayuela ML, Marionneau-Lambot S, Oullier T, Guibon R, Fromont G, Gutierrez-Pajares JL, Domingo I, Piver E, Moreau A, Burlaud-Gaillard J, Frank PG, Chevalier S, Besson P, Roger S. SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer. Nat Commun. 2016 12 05; 7:13648.

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Syeda R, Florendo MN, Cox CD, Kefauver JM, Santos JS, Martinac B, Patapoutian A. Piezo1 Channels Are Inherently Mechanosensitive. Cell Rep. 2016 11 08; 17(7):1739-1746.

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Bisen S, Seleverstov O, Belani J, Rychnovsky S, Dopico AM, Bukiya AN. Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction. Biochim Biophys Acta. 2016 11; 1861(11):1756-1766.

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Fineberg JD, Szanto TG, Panyi G, Covarrubias M. Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions. Sci Rep. 2016 08 09; 6:31131.

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