"Porphyrias, Hepatic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
| Descriptor ID |
D017094
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| MeSH Number(s) |
C06.552.830 C16.320.850.742 C17.800.827.742 C18.452.811.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Porphyrias, Hepatic".
Below are MeSH descriptors whose meaning is more specific than "Porphyrias, Hepatic".
This graph shows the total number of publications written about "Porphyrias, Hepatic" by people in this website by year, and whether "Porphyrias, Hepatic" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
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Below are the most recent publications written about "Porphyrias, Hepatic" by people in Profiles.
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Frank J, McGrath JA, Poh-Fitzpatrick MB, Hawk JL, Christiano AM. Mutations in the translation initiation codon of the protoporphyrinogen oxidase gene underlie variegate porphyria. Clin Exp Dermatol. 1999 Jul; 24(4):296-301.
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McGrath JA, Hawk JL, Graham RM, Christiano AM. Lack of the R59W South African founder effect mutation in protoporphyrinogen oxidase in a British patient with homozygous variegate porphyria. Br J Dermatol. 1997 Feb; 136(2):292.
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Potter C, Tolaymat N, Bobo R, Sharp H, Rank J, Bloomer J. Hematin therapy in children with protoporphyric liver disease. J Pediatr Gastroenterol Nutr. 1996 Nov; 23(4):402-7.