GTP-Binding Protein alpha Subunits, Gi-Go

"GTP-Binding Protein alpha Subunits, Gi-Go" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.

Descriptor ID	D019206
MeSH Number(s)	D08.811.277.040.330.300.200.100.200 D12.644.360.360.100.200 D12.776.157.325.332.100.200 D12.776.476.375.100.200 D12.776.543.325.100.200
Concept/Terms	GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Protein alpha Subunits, Gi-Go GTP Binding Protein alpha Subunits, Gi Go G-Protein, Gi-Go Subunits G Protein, Gi Go Subunits Gi-Go Subunits G-Protein Subunits G-Protein, Gi-Go Gi-Go G-Proteins G-Proteins, Gi-Go Gi Go G Proteins G-Protein, Gi-Go alpha Family G Protein, Gi Go alpha Family GTP-Binding Protein alpha Subunit, GoC GTP-Binding Protein alpha Subunit, GoC GTP Binding Protein alpha Subunit, GoC G Protein Subunit alphaoC GTP-Binding Protein alpha Subunit, Go1 GTP-Binding Protein alpha Subunit, Go1 GTP Binding Protein alpha Subunit, Go1 G-Protein, Go1 Subunit G Protein, Go1 Subunit Go1 Subunit G-Protein Subunit G-Protein, Go1 G(o1)alpha GTP-Binding Protein alpha Subunit, GoA GTP-Binding Protein alpha Subunit, GoA GTP Binding Protein alpha Subunit, GoA G Protein Subunit alphaoA GTP-Binding Protein alpha Subunit, Go GTP-Binding Protein alpha Subunit, Go GTP Binding Protein alpha Subunit, Go Guanine Nucleotide-Binding Protein Go Guanine Nucleotide Binding Protein Go Go Alpha Subunit Alpha Subunit, Go Subunit, Go Alpha G-Protein, Inhibitory Go G Protein, Inhibitory Go Go G-Protein, Inhibitory Inhibitory Go G-Protein G-Protein, Go Subunit G Protein, Go Subunit Go Subunit G-Protein Subunit G-Protein, Go G Protein Go Go, G Protein G(o) Protein GTP-Binding Protein alpha Subunit, Gi GTP-Binding Protein alpha Subunit, Gi GTP Binding Protein alpha Subunit, Gi Gi, Inhibitory G-Protein Gi, Inhibitory G Protein Inhibitory G-Protein Gi G-Protein, Inhibitory Gi G Protein, Inhibitory Gi Gi G-Protein, Inhibitory Inhibitory Gi G-Protein G-Protein, Gi Subunit G Protein, Gi Subunit Gi Subunit G-Protein Subunit G-Protein, Gi Gi alpha Subunit Subunit, Gi alpha alpha Subunit, Gi Ni Protein Gi-Alpha Protein Gi Alpha Protein

Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits, Gi-Go".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
GTP Phosphohydrolases [D08.811.277.040.330]
GTP-Binding Proteins [D08.811.277.040.330.300]
Heterotrimeric GTP-Binding Proteins [D08.811.277.040.330.300.200]
GTP-Binding Protein alpha Subunits [D08.811.277.040.330.300.200.100]
GTP-Binding Protein alpha Subunits, Gi-Go [D08.811.277.040.330.300.200.100.200]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Heterotrimeric GTP-Binding Proteins [D12.644.360.360]
GTP-Binding Protein alpha Subunits [D12.644.360.360.100]
GTP-Binding Protein alpha Subunits, Gi-Go [D12.644.360.360.100.200]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
GTP-Binding Proteins [D12.776.157.325]
Heterotrimeric GTP-Binding Proteins [D12.776.157.325.332]
GTP-Binding Protein alpha Subunits [D12.776.157.325.332.100]
GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.157.325.332.100.200]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]
GTP-Binding Protein alpha Subunits [D12.776.476.375.100]
GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.476.375.100.200]
Membrane Proteins [D12.776.543]
Heterotrimeric GTP-Binding Proteins [D12.776.543.325]
GTP-Binding Protein alpha Subunits [D12.776.543.325.100]
GTP-Binding Protein alpha Subunits, Gi-Go [D12.776.543.325.100.200]

Below are MeSH descriptors whose meaning is related to "GTP-Binding Protein alpha Subunits, Gi-Go".

Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits, Gi-Go".

GTP-Binding Protein alpha Subunits, Gi-Go
GTP-Binding Protein alpha Subunit, Gi2

publications

Timeline | Most Recent

This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits, Gi-Go" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits, Gi-Go" was a major or minor topic of these publications.

Bar chart showing 20 publications over 14 distinct years, with a maximum of 2 publications in 2002 and 2004 and 2009 and 2010 and 2011 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	1	1	2
2003	1	0	1
2004	1	1	2
2005	1	0	1
2007	1	0	1
2009	1	1	2
2010	2	0	2
2011	2	0	2
2013	1	1	2
2014	1	0	1
2017	0	1	1
2018	1	0	1
2023	0	1	1

Below are the most recent publications written about "GTP-Binding Protein alpha Subunits, Gi-Go" by people in Profiles.

Lin R, Kenyon A, Wang ZX, Cai J, Iacovitti L, Kenyon LC. Pilocytic astrocytoma harboring a novel GNAI3-BRAF fusion. Neuropathology. 2023 Oct; 43(5):391-395.

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Cheng L, Al-Owais M, Covarrubias ML, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo NA. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. J Biol Chem. 2018 07 13; 293(28):11022-11032.

View in: PubMed
Wang J, Luo J, Aryal DK, Wetsel WC, Nass R, Benovic JL. G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. J Biol Chem. 2017 04 07; 292(14):5943-5956.

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Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol. 2014 Jul 01; 307(1):H66-72.

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Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW, Bouvier M. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5088-97.

View in: PubMed
Gordon CT, Vuillot A, Marlin S, Gerkes E, Henderson A, AlKindy A, Holder-Espinasse M, Park SS, Omarjee A, Sanchis-Borja M, Bdira EB, Oufadem M, Sikkema-Raddatz B, Stewart A, Palmer R, McGowan R, Petit F, Delobel B, Speicher MR, Aurora P, Kilner D, Pellerin P, Simon M, Bonnefont JP, Tobias ES, Garc?a-Mi?a?r S, Bitner-Glindzicz M, Lindholm P, Meijer BA, Abadie V, Denoyelle F, Vazquez MP, Rotky-Fast C, Couloigner V, Pierrot S, Manach Y, Breton S, Hendriks YM, Munnich A, Jakobsen L, Kroisel P, Lin A, Kaban LB, Basel-Vanagaite L, Wilson L, Cunningham ML, Lyonnet S, Amiel J. Heterogeneity of mutational mechanisms and modes of inheritance in auriculocondylar syndrome. J Med Genet. 2013 Mar; 50(3):174-86.

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Polizio AH, Chinchilla P, Chen X, Manning DR, Riobo NA. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Sci Signal. 2011 Nov 22; 4(200):pt7.

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Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR, Riobo NA. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem. 2011 Jun 03; 286(22):19589-96.

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Chen XP, Yang W, Fan Y, Luo JS, Hong K, Wang Z, Yan JF, Chen X, Lu JX, Benovic JL, Zhou NM. Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i). Br J Pharmacol. 2010 Dec; 161(8):1817-34.

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Li G, Shi Y, Huang H, Zhang Y, Wu K, Luo J, Sun Y, Lu J, Benovic JL, Zhou N. Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3. J Biol Chem. 2010 Jul 16; 285(29):22605-18.

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