GTP-Binding Protein alpha Subunits, G12-G13
"GTP-Binding Protein alpha Subunits, G12-G13" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed family of heterotrimeric GTP-binding protein alpha subunits that signal through interactions with a variety of second messengers as GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; and HEAT SHOCK PROTEINS. The G12-G13 part of the name is also spelled G12/G13.
| Descriptor ID |
D044365
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| MeSH Number(s) |
D08.811.277.040.330.300.200.100.100 D12.644.360.360.100.100 D12.776.157.325.332.100.100 D12.776.476.375.100.100 D12.776.543.325.100.100
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| Concept/Terms |
GTP-Binding Protein alpha Subunits, G12-G13- GTP-Binding Protein alpha Subunits, G12-G13
- GTP Binding Protein alpha Subunits, G12 G13
- G-Protein, G12-G13 alpha Subunits
- G Protein, G12 G13 alpha Subunits
- G-Protein, G12-G13 alpha Family
- G Protein, G12 G13 alpha Family
GTP-Binding Protein alpha Subunit, G13- GTP-Binding Protein alpha Subunit, G13
- GTP Binding Protein alpha Subunit, G13
- G13 G-Protein
- G-Protein, G13
- G13 G Protein
- G(13) Protein
- Galpha13 Protein
- G-Protein, G13 Subunit
- G Protein, G13 Subunit
- G13 Subunit G-Protein
- Subunit G-Protein, G13
- G13 Protein
- G alpha13 Protein
- alpha13 Protein, G
GTP-Binding Protein alpha Subunit, G12- GTP-Binding Protein alpha Subunit, G12
- GTP Binding Protein alpha Subunit, G12
- G12 alpha Protein
- alpha Protein, G12
- G12 Protein
- Protein, G12
- G-Protein, G12 Subunit
- G Protein, G12 Subunit
- G12 Subunit G-Protein
- Subunit G-Protein, G12
- G alpha12 Protein
- alpha12 Protein, G
- Galpha12 Protein
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Below are MeSH descriptors whose meaning is more general than "GTP-Binding Protein alpha Subunits, G12-G13".
Below are MeSH descriptors whose meaning is more specific than "GTP-Binding Protein alpha Subunits, G12-G13".
This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits, G12-G13" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits, G12-G13" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2005 | 2 | 1 | 3 |
| 2009 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "GTP-Binding Protein alpha Subunits, G12-G13" by people in Profiles.
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Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. Arterioscler Thromb Vasc Biol. 2018 07; 38(7):1632-1643.
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Yoo EJ, Cao G, Koziol-White CJ, Ojiaku CA, Sunder K, Jude JA, Michael JV, Lam H, Pushkarsky I, Damoiseaux R, Di Carlo D, Ahn K, An SS, Penn RB, Panettieri RA. Ga12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner. Br J Pharmacol. 2017 Dec; 174(23):4383-4395.
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Quoyer J, Janz JM, Luo J, Ren Y, Armando S, Lukashova V, Benovic JL, Carlson KE, Hunt SW, Bouvier M. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5088-97.
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Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fern?ndez-Zapico ME, Manning DR. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem. 2011 Sep 02; 286(35):30714-30722.
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Chahdi A, Sorokin A. The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1330-5.
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Bhattacharyya R, Banerjee J, Khalili K, Wedegaertner PB. Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cell Signal. 2009 Jun; 21(6):996-1006.
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McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE. Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem. 2005 Jul 01; 280(26):25048-59.
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Grabocka E, Wedegaertner PB. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. Oncogene. 2005 Mar 24; 24(13):2155-65.
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Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends Pharmacol Sci. 2005 Mar; 26(3):146-54.
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Holinstat M, Mehta D, Kozasa T, Minshall RD, Malik AB. Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem. 2003 Aug 01; 278(31):28793-8.