MPTP Poisoning

"MPTP Poisoning" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

Descriptor ID	D020267
MeSH Number(s)	C10.228.140.079.862.800.300 C10.228.662.600.700.250 C10.720.606 C25.723.705.400
Concept/Terms	MPTP Poisoning MPTP Poisoning Poisoning, MPTP Neurotoxicity Syndrome, MPTP MPTP-Induced Parkinsonism MPTP Induced Parkinsonism Parkinsonism, MPTP-Induced Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP Neurotoxicity Syndrome MPTP Neurotoxicity Syndromes Neurotoxicity Syndromes, MPTP MPTP-Induced Degeneration of the Striatum MPTP-Induced Degeneration of the Striatum MPTP Induced Degeneration of the Striatum

Below are MeSH descriptors whose meaning is more general than "MPTP Poisoning".

Diseases [C]
Nervous System Diseases [C10]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Basal Ganglia Diseases [C10.228.140.079]
Parkinsonian Disorders [C10.228.140.079.862]
Parkinson Disease, Secondary [C10.228.140.079.862.800]
MPTP Poisoning [C10.228.140.079.862.800.300]
Movement Disorders [C10.228.662]
Parkinsonian Disorders [C10.228.662.600]
Parkinson Disease, Secondary [C10.228.662.600.700]
MPTP Poisoning [C10.228.662.600.700.250]
Neurotoxicity Syndromes [C10.720]
MPTP Poisoning [C10.720.606]
Chemically-Induced Disorders [C25]
Poisoning [C25.723]
Neurotoxicity Syndromes [C25.723.705]
MPTP Poisoning [C25.723.705.400]

Below are MeSH descriptors whose meaning is related to "MPTP Poisoning".

Below are MeSH descriptors whose meaning is more specific than "MPTP Poisoning".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MPTP Poisoning" by people in this website by year, and whether "MPTP Poisoning" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2005	0	1	1
2006	1	0	1
2009	1	0	1
2012	2	0	2
2014	1	0	1
2015	1	0	1
2016	1	0	1
2017	1	0	1

Below are the most recent publications written about "MPTP Poisoning" by people in Profiles.

Yoon KW, Yang HS, Kim YM, Kim Y, Kang S, Sun W, Naik UP, Parise LV, Choi EJ. CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. Sci Rep. 2017 09 22; 7(1):12178.

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Smeyne RJ, Breckenridge CB, Beck M, Jiao Y, Butt MT, Wolf JC, Zadory D, Minnema DJ, Sturgess NC, Travis KZ, Cook AR, Smith LL, Botham PA. Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice. PLoS One. 2016; 11(10):e0164094.

View in: PubMed
Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne RJ. HIF1a is necessary for exercise-induced neuroprotection while HIF2a is needed for dopaminergic neuron survival in the substantia nigra pars compacta. Neuroscience. 2015 Jun 04; 295:23-38.

View in: PubMed
Schneider JS, Ault ME, Anderson DW. Retinal pathology detected by optical coherence tomography in an animal model of Parkinson's disease. Mov Disord. 2014 Oct; 29(12):1547-51.

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Adeosun SO, Hou X, Jiao Y, Zheng B, Henry S, Hill R, He Z, Pani A, Kyle P, Ou X, Mosley T, Farley JM, Stockmeier C, Paul I, Bigler S, Brinton RD, Smeyne R, Wang JM. Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. PLoS One. 2012; 7(11):e50040.

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Gerecke KM, Jiao Y, Pagala V, Smeyne RJ. Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice. PLoS One. 2012; 7(8):e43250.

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Chen PC, Vargas MR, Pani AK, Smeyne RJ, Johnson DA, Kan YW, Johnson JA. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2933-8.

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Anderson DW, Bradbury KA, Schneider JS. Neuroprotection in Parkinson models varies with toxin administration protocol. Eur J Neurosci. 2006 Dec; 24(11):3174-82.

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Faherty CJ, Raviie Shepherd K, Herasimtschuk A, Smeyne RJ. Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):170-9.

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Hamre K, Tharp R, Poon K, Xiong X, Smeyne RJ. Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: quantitative analysis in seven strains of Mus musculus. Brain Res. 1999 May 15; 828(1-2):91-103.

View in: PubMed

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