DNA Topoisomerases, Type II
"DNA Topoisomerases, Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
| Descriptor ID |
D004250
|
| MeSH Number(s) |
D08.811.399.403.741
|
| Concept/Terms |
DNA Topoisomerases, Type II- DNA Topoisomerases, Type II
- Type II DNA Topoisomerase
- Topoisomerase II
- DNA Topoisomerase (ATP-Hydrolysing)
- DNA Topoisomerase II
- DNA Type 2 Topoisomerase
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type II".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type II".
This graph shows the total number of publications written about "DNA Topoisomerases, Type II" by people in this website by year, and whether "DNA Topoisomerases, Type II" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 2 | 0 | 2 |
| 2001 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "DNA Topoisomerases, Type II" by people in Profiles.
-
Boisgerault N, Kottke T, Pulido J, Thompson J, Diaz RM, Rommelfanger-Konkol D, Embry A, Saenz D, Poeschla E, Pandha H, Harrington K, Melcher A, Selby P, Vile R. Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse. Mol Ther. 2013 Aug; 21(8):1507-16.
-
Hansel DE, Ashfaq R, Rahman A, Wanzer D, Yeo CJ, Wilentz RE, Maitra A. A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening andtreatment. Am J Clin Pathol. 2005 Jan; 123(1):28-35.
-
DiPaola RS, Chenven ES, Shih WJ, Lin Y, Amenta P, Goodin S, Shumate A, Capanna T, Cardiella M, Cummings KB, Aisner J, Todd MB. Mitoxantrone in patients with prostate specific antigen progression after local therapy for prostate carcinoma. Cancer. 2001 Oct 15; 92(8):2065-71.
-
Mirski SE, Voskoglou-Nomikos T, Young LC, Deeley RG, Campling BG, Gerlach JH, Cole SP. Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue. Lab Invest. 2000 Jun; 80(6):787-95.
-
Mirski SE, Sparks KE, Yu Q, Lang AJ, Jain N, Campling BG, Cole SP. A truncated cytoplasmic topoisomerase IIalpha in a drug-resistant lung cancer cell line is encoded by a TOP2A allele with a partial deletion of exon 34. Int J Cancer. 2000 Feb 15; 85(4):534-9.
-
Sullivan GF, Amenta PS, Villanueva JD, Alvarez CJ, Yang JM, Hait WN. The expression of drug resistance gene products during the progression of human prostate cancer. Clin Cancer Res. 1998 Jun; 4(6):1393-403.
-
Jain N, Lam YM, Pym J, Campling BG. Mechanisms of resistance of human small cell lung cancer lines selected in VP-16 and cisplatin. Cancer. 1996 May 01; 77(9):1797-808.
-
Horiuchi K, Ravetch JV, Zinder ND. DNA replication of bacteriophage f1 in vivo. Cold Spring Harb Symp Quant Biol. 1979; 43 Pt 1:389-99.