Protein Phosphatase 1

"Protein Phosphatase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.

Descriptor ID	D054645
MeSH Number(s)	D08.811.277.352.650.625.687
Concept/Terms	Protein Phosphatase 1 Protein Phosphatase 1 Protein Phosphatase-1 Type 1 Serine Threonine Protein Phosphatase PP1c Enzyme Protein Phosphatase 1, Regulatory Subunit Protein Phosphatase 1, Regulatory Subunit Protein Phosphatase 1, Inhibitory Subunit Protein Phosphatase 1, Catalytic Subunit Protein Phosphatase 1, Catalytic Subunit Protein Phosphatase 1C Protein Phosphatase 1, Catalytic Subunit, gamma1 Isoform Protein Phosphatase 1, Catalytic Subunit, gamma1 Isoform Phosphoprotein Phosphatase-1 gamma 1 Phosphoprotein Phosphatase 1 gamma 1 Protein Phosphatase 1, Catalytic Subunit, beta Isoform Protein Phosphatase 1, Catalytic Subunit, beta Isoform Protein Serine-Threonine Phosphatase 1 beta Protein Serine Threonine Phosphatase 1 beta Protein-Serine-Threonine Phosphatase 1 beta Protein Phosphatase 1, Catalytic Subunit, delta Isoform Protein Phosphatase 1, Catalytic Subunit, delta Isoform Phosphoprotein Phosphatase-1 delta Phosphatase-1 delta, Phosphoprotein Phosphoprotein Phosphatase 1 delta Protein Phosphatase 1, Catalytic Subunit, gamma Isoform Protein Phosphatase 1, Catalytic Subunit, gamma Isoform Protein Phosphatase 1gamma Protein Phosphatase-1G Protein Phosphatase 1G Protein Phosphatase 1C gamma Protein Phosphatase 1, Catalytic Subunit, gamma2 Isoform Protein Phosphatase 1, Catalytic Subunit, gamma2 Isoform Protein Phosphatase-1 gamma 2 Protein Phosphatase 1 gamma 2 Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Protein Phosphatase-1 alpha Protein Phosphatase 1 alpha

Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Protein Phosphatase 1 [D08.811.277.352.650.625.687]

Below are MeSH descriptors whose meaning is related to "Protein Phosphatase 1".

Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Phosphatase 1" by people in this website by year, and whether "Protein Phosphatase 1" was a major or minor topic of these publications.

Bar chart showing 26 publications over 12 distinct years, with a maximum of 4 publications in 2004 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	3	3
2003	0	3	3
2004	0	4	4
2005	1	2	3
2006	0	1	1
2007	1	3	4
2008	0	2	2
2009	0	2	2
2012	0	1	1
2016	1	0	1
2017	1	0	1
2023	0	1	1

Below are the most recent publications written about "Protein Phosphatase 1" by people in Profiles.

Kirkbride JA, Nilsson GY, Kim JI, Takeya K, Tanaka Y, Tokumitsu H, Suizu F, Eto M. PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. Biomolecules. 2023 12 04; 13(12).

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Takai A, Eto M, Hirano K, Takeya K, Wakimoto T, Watanabe M. Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology. J Physiol Sci. 2018 Jan; 68(1):1-17.

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Gripp KW, Aldinger KA, Bennett JT, Baker L, Tusi J, Powell-Hamilton N, Stabley D, Sol-Church K, Timms AE, Dobyns WB. A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair. Am J Med Genet A. 2016 09; 170(9):2237-47.

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Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012 Jul; 19(7):1152-61.

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Eto M. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem. 2009 Dec 18; 284(51):35273-7.

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Freitas MR, Eto M, Kirkbride JA, Schott C, Sassard J, Stoclet JC. Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle. Fundam Clin Pharmacol. 2009 Apr; 23(2):169-78.

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Neppl RL, Lubomirov LT, Momotani K, Pfitzer G, Eto M, Somlyo AV. Thromboxane A2-induced bi-directional regulation of cerebral arterial tone. J Biol Chem. 2009 Mar 06; 284(10):6348-60.

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Ohtsu H, Higuchi S, Shirai H, Eguchi K, Suzuki H, Hinoki A, Brailoiu E, Eckhart AD, Frank GD, Eguchi S. Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells. Endocrinology. 2008 Jul; 149(7):3569-75.

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Novoyatleva T, Heinrich B, Tang Y, Benderska N, Butchbach ME, Lorson CL, Lorson MA, Ben-Dov C, Fehlbaum P, Bracco L, Burghes AH, Bollen M, Stamm S. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet. 2008 Jan 01; 17(1):52-70.

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Cheng J, Kydd AR, Nakase K, Noonan KM, Murakami A, Tao H, Dwyer M, Xu C, Zhu Q, Marasco WA. Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood. 2007 Sep 15; 110(6):2110-20.

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