Protein Phosphatase 2

"Protein Phosphatase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.

Descriptor ID	D054648
MeSH Number(s)	D08.811.277.352.650.625.706 D12.644.360.583 D12.776.476.561
Concept/Terms	Protein Phosphatase 2 Protein Phosphatase 2 Protein Phosphatase-2A Protein Phosphatase 2A Protein Phosphatase 2, Catalytic Subunit, alpha Isoform Protein Phosphatase 2, Catalytic Subunit, alpha Isoform PPP2CA Phosphatase Phosphatase, PPP2CA Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2, Catalytic Subunit, beta Isoform Protein Phosphatase 2A, Catalytic Subunit, beta Isoform PPP2CB Phosphatase Phosphatase, PPP2CB Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit A , alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2A, Regulatory Subunit B, alpha Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Protein Phosphatase 2A, Regulatory Subunit B, beta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Protein Phosphatase 2A, Regulatory Subunit B, delta Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2A, Regulatory Subunit B, gamma Isoform Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Catalytic Subunit Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Protein Phosphatase 2A, Regulatory Subunit A, beta Isoform

Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Phosphoprotein Phosphatases [D08.811.277.352.650.625]
Protein Phosphatase 2 [D08.811.277.352.650.625.706]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Protein Phosphatase 2 [D12.644.360.583]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Protein Phosphatase 2 [D12.776.476.561]

Below are MeSH descriptors whose meaning is related to "Protein Phosphatase 2".

Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Phosphatase 2" by people in this website by year, and whether "Protein Phosphatase 2" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2000 and 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2001	0	1	1
2003	0	2	2
2004	0	1	1
2006	0	1	1
2011	1	0	1
2012	0	1	1
2017	1	0	1
2021	1	0	1

Below are the most recent publications written about "Protein Phosphatase 2" by people in Profiles.

Kitazawa T, Matsui T, Katsuki S, Goto A, Akagi K, Hatano N, Tokumitsu H, Takeya K, Eto M. A temporal Ca2+ desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKK?/PP2A pathways. Am J Physiol Cell Physiol. 2021 09 01; 321(3):C549-C558.

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Takai A, Eto M, Hirano K, Takeya K, Wakimoto T, Watanabe M. Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology. J Physiol Sci. 2018 Jan; 68(1):1-17.

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Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein-Szanto AJ, Bagella L, Castronovo M, Giordano A. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012 Jul; 19(7):1152-61.

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Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):E1120-7.

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Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 01; 66(1):331-42.

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Yusa S, Catina TL, Campbell KS. KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2). J Immunol. 2004 Jun 15; 172(12):7385-92.

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Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE. Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein. Protein Expr Purif. 2003 Sep; 31(1):19-33.

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Yusa S, Campbell KS. Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) can play a direct role in the inhibitory function of killer cell Ig-like receptors in human NK cells. J Immunol. 2003 May 01; 170(9):4539-47.

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Powell DJ, Russell JP, Li G, Kuo BA, Fidanza V, Huebner K, Rothstein JL. Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice. Oncogene. 2001 May 31; 20(25):3235-46.

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Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem. 2000 Feb 25; 275(8):5535-44.

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