ELAV Proteins

"ELAV Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of RRM PROTEINS that are homologues of ELAV protein, Drosophila. They were initially identified in humans as the targets of autoantibodies in patients with PARANEOPLASTIC ENCEPHALOMYELITIS. They regulate GENE EXPRESSION at the post-transcriptional level.

Descriptor ID	D051959
MeSH Number(s)	D12.776.157.725.813.500 D12.776.631.520 D12.776.664.962.813.500
Concept/Terms	ELAV Proteins ELAV Proteins Proteins, ELAV ELAV Protein Protein, ELAV Hu Antigens Antigens, Hu Embryonic Lethal, Abnormal Vision-Like Proteins Embryonic Lethal, Abnormal Vision Like Proteins Hu Paraneoplastic Encephalomyelitis Antigens

Below are MeSH descriptors whose meaning is more general than "ELAV Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
RNA-Binding Proteins [D12.776.157.725]
RNA Recognition Motif Proteins [D12.776.157.725.813]
ELAV Proteins [D12.776.157.725.813.500]
Nerve Tissue Proteins [D12.776.631]
ELAV Proteins [D12.776.631.520]
Nucleoproteins [D12.776.664]
RNA-Binding Proteins [D12.776.664.962]
RNA Recognition Motif Proteins [D12.776.664.962.813]
ELAV Proteins [D12.776.664.962.813.500]

Below are MeSH descriptors whose meaning is related to "ELAV Proteins".

Below are MeSH descriptors whose meaning is more specific than "ELAV Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "ELAV Proteins" by people in this website by year, and whether "ELAV Proteins" was a major or minor topic of these publications.

Bar chart showing 14 publications over 7 distinct years, with a maximum of 5 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2009	0	2	2
2010	2	3	5
2012	1	0	1
2013	0	2	2
2014	2	0	2
2023	0	1	1

Below are the most recent publications written about "ELAV Proteins" by people in Profiles.

Finan JM, Sutton TL, Dixon DA, Brody JR. Targeting the RNA-Binding Protein HuR in Cancer. Cancer Res. 2023 11 01; 83(21):3507-3516.

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McAllister F, Pineda DM, Jimbo M, Lal S, Burkhart RA, Moughan J, Winter KA, Abdelmohsen K, Gorospe M, Acosta Ade J, Lankapalli RH, Winter JM, Yeo CJ, Witkiewicz AK, Iacobuzio-Donahue CA, Laheru D, Brody JR. dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer: a dual-institutional follow-up with the RTOG 9704 trial. Cancer Biol Ther. 2014 Jun 01; 15(6):688-98.

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Lal S, Burkhart RA, Beeharry N, Bhattacharjee V, Londin ER, Cozzitorto JA, Romeo C, Jimbo M, Norris ZA, Yeo CJ, Sawicki JA, Winter JM, Rigoutsos I, Yen TJ, Brody JR. HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells. Cancer Res. 2014 Feb 15; 74(4):1128-40.

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Burkhart RA, Pineda DM, Chand SN, Romeo C, Londin ER, Karoly ED, Cozzitorto JA, Rigoutsos I, Yeo CJ, Brody JR, Winter JM. HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer. RNA Biol. 2013 Aug; 10(8):1312-23.

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Hongpaisan J, Xu C, Sen A, Nelson TJ, Alkon DL. PKC activation during training restores mushroom spine synapses and memory in the aged rat. Neurobiol Dis. 2013 Jul; 55:44-62.

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Pineda DM, Rittenhouse DW, Valley CC, Cozzitorto JA, Burkhart RA, Leiby B, Winter JM, Weber MC, Londin ER, Rigoutsos I, Yeo CJ, Gorospe M, Witkiewicz AK, Sachs JN, Brody JR. HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells. Cancer Biol Ther. 2012 Aug; 13(10):946-55.

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Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR. T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade. PLoS One. 2010 Dec 29; 5(12):e14450.

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Brody JR, Gonye GE. HuR's role in gemcitabine efficacy: an exception or opportunity? Wiley Interdiscip Rev RNA. 2011 May-Jun; 2(3):435-44.

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Williams TK, Costantino CL, Bildzukewicz NA, Richards NG, Rittenhouse DW, Einstein L, Cozzitorto JA, Keen JC, Dasgupta A, Gorospe M, Gonye GE, Yeo CJ, Witkiewicz AK, Brody JR. pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs. PLoS One. 2010 Nov 29; 5(11):e15455.

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Karipcin FS, Ensari TA, Kayisli UA, Guzel E, Kallen CB, Seli E. The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium. Reprod Sci. 2011 Feb; 18(2):145-55.

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