Voltage-Gated Sodium Channels
"Voltage-Gated Sodium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane proteins that selectively conduct SODIUM ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. They typically have a multimeric structure with a core alpha subunit that defines the sodium channel subtype and several beta subunits that modulate sodium channel activity.
| Descriptor ID |
D061566
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| MeSH Number(s) |
D12.776.157.530.400.875.750 D12.776.543.550.450.875.750 D12.776.543.585.400.875.750 D12.776.631.960
|
| Concept/Terms |
Voltage-Gated Sodium Channels- Voltage-Gated Sodium Channels
- Channels, Voltage-Gated Sodium
- Voltage Gated Sodium Channels
- Sodium Channels, Voltage-Gated
- Sodium Channels, Voltage Gated
|
Below are MeSH descriptors whose meaning is more general than "Voltage-Gated Sodium Channels".
Below are MeSH descriptors whose meaning is more specific than "Voltage-Gated Sodium Channels".
This graph shows the total number of publications written about "Voltage-Gated Sodium Channels" by people in this website by year, and whether "Voltage-Gated Sodium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Voltage-Gated Sodium Channels" by people in Profiles.
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Yang E, Bu W, Suma A, Carnevale V, Grasty KC, Loll PJ, Woll K, Bhanu N, Garcia BA, Eckenhoff RG, Covarrubias M. Binding Sites and the Mechanism of Action of Propofol and a Photoreactive Analogue in Prokaryotic Voltage-Gated Sodium Channels. ACS Chem Neurosci. 2021 10 20; 12(20):3898-3914.
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Clatot J, Neyroud N, Cox R, Souil C, Huang J, Guicheney P, Antzelevitch C. Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies. Int J Mol Sci. 2020 Jul 17; 21(14).
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Yang E, Granata D, Eckenhoff RG, Carnevale V, Covarrubias M. Propofol inhibits prokaryotic voltage-gated Na+ channels by promoting activation-coupled inactivation. J Gen Physiol. 2018 09 03; 150(9):1299-1316.
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Yang E, Zhi L, Liang Q, Covarrubias M. Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics. Methods Enzymol. 2018; 602:339-368.
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Covarrubias M, Barber AF, Carnevale V, Treptow W, Eckenhoff RG. Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics. Biophys J. 2015 Nov 17; 109(10):2003-11.
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Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S. Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Sci Signal. 2014 Nov 18; 7(352):ra109.