"DNA Breaks" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruptions in the sugar-phosphate backbone of DNA.
| Descriptor ID |
D053960
|
| MeSH Number(s) |
G05.200.210
|
| Concept/Terms |
DNA Breaks- DNA Breaks
- Break, DNA
- Breaks, DNA
- DNA Break
|
Below are MeSH descriptors whose meaning is more general than "DNA Breaks".
Below are MeSH descriptors whose meaning is more specific than "DNA Breaks".
This graph shows the total number of publications written about "DNA Breaks" by people in this website by year, and whether "DNA Breaks" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 2 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Breaks" by people in Profiles.
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Velagapudi UK, Rouleau-Turcotte ?, Billur R, Shao X, Patil M, Black BE, Pascal JM, Talele TT. Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks. Biochem J. 2024 03 20; 481(6):437-460.
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Rouleau-Turcotte ?, Pascal JM. Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin. Mol Cell. 2020 11 19; 80(4):560-561.
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Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Structural basis for allosteric PARP-1 retention on DNA breaks. Science. 2020 04 03; 368(6486).
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Black SJ, Ozdemir AY, Kashkina E, Kent T, Rusanov T, Ristic D, Shin Y, Suma A, Hoang T, Chandramouly G, Siddique LA, Borisonnik N, Sullivan-Reed K, Mallon JS, Skorski T, Carnevale V, Murakami KS, Wyman C, Pomerantz RT. Molecular basis of microhomology-mediated end-joining by purified full-length Pol?. Nat Commun. 2019 09 27; 10(1):4423.
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Pascal JM. The comings and goings of PARP-1 in response to DNA damage. DNA Repair (Amst). 2018 11; 71:177-182.
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Riccio AA, Cingolani G, Pascal JM. PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Res. 2016 Feb 29; 44(4):1691-702.
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Dawicki-McKenna JM, Langelier MF, DeNizio JE, Riccio AA, Cao CD, Karch KR, McCauley M, Steffen JD, Black BE, Pascal JM. PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain. Mol Cell. 2015 Dec 03; 60(5):755-768.
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Langelier MF, Riccio AA, Pascal JM. PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1. Nucleic Acids Res. 2014 Jul; 42(12):7762-75.