Bone Morphogenetic Protein 1
"Bone Morphogenetic Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bone morphogenetic protein family member that includes an active tolloid-like metalloproteinase domain. The metalloproteinase activity of bone morphogenetic protein 1 is specific for the removal of the C-propeptide of PROCOLLAGEN and may act as a regulator of EXTRACELLULAR MATRIX deposition. Alternative splicing of MRNA for bone morphogenetic protein 1 results in the production of several PROTEIN ISOFORMS.
| Descriptor ID |
D055395
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| MeSH Number(s) |
D08.811.277.656.300.480.525.700.049 D08.811.277.656.675.374.525.700.900.500 D12.644.276.848.049 D12.644.276.948.500 D12.644.276.954.200.100 D12.776.467.836.049 D12.776.467.942.200.100 D12.776.467.948.500 D23.529.942.200.100 D23.529.948.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Bone Morphogenetic Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Bone Morphogenetic Protein 1".
This graph shows the total number of publications written about "Bone Morphogenetic Protein 1" by people in this website by year, and whether "Bone Morphogenetic Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bone Morphogenetic Protein 1" by people in Profiles.
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Chung HJ, Steplewski A, Chung KY, Uitto J, Fertala A. Collagen fibril formation. A new target to limit fibrosis. J Biol Chem. 2008 Sep 19; 283(38):25879-86.
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Gonzalez EM, Reed CC, Bix G, Fu J, Zhang Y, Gopalakrishnan B, Greenspan DS, Iozzo RV. BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem. 2005 Feb 25; 280(8):7080-7.
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Colombo M, Brittingham RJ, Klement JF, Majsterek I, Birk DE, Uitto J, Fertala A. Procollagen VII self-assembly depends on site-specific interactions and is promoted by cleavage of the NC2 domain with procollagen C-proteinase. Biochemistry. 2003 Oct 07; 42(39):11434-42.
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Majsterek I, McAdams E, Adachi E, Dhume ST, Fertala A. Prospects and limitations of the rational engineering of fibrillar collagens. Protein Sci. 2003 Sep; 12(9):2063-72.
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Fertala A, Sieron AL, Adachi E, Jimenez SA. Collagen II containing a Cys substitution for Arg-alpha1-519: abnormal interactions of the mutated molecules with collagen IX. Biochemistry. 2001 Dec 04; 40(48):14422-8.
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Zafarullah K, Sieron AL, Fertala A, Tromp G, Kuivaniemi H, Prockop DJ. A recombinant homotrimer of type I procollagen that lacks the central two D-periods. The thermal stability of the triple helix is decreased by 2 to 4 degrees C. Matrix Biol. 1997 Nov; 16(5):245-53.
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Li SW, Sieron AL, Fertala A, Hojima Y, Arnold WV, Prockop DJ. The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):5127-30.