CLOCK Proteins

"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

Descriptor ID	D056926
MeSH Number(s)	D08.811.913.050.134.415.500.049 D12.644.128.100 D12.776.189.200 D12.776.260.103.562 D12.776.930.125.562
Concept/Terms	CLOCK Proteins CLOCK Proteins Circadian Locomotor Output Cycles Kaput Proteins CLOCK Protein

Below are MeSH descriptors whose meaning is more general than "CLOCK Proteins".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Acetyltransferases [D08.811.913.050.134]
Lysine Acetyltransferases [D08.811.913.050.134.415]
Histone Acetyltransferases [D08.811.913.050.134.415.500]
CLOCK Proteins [D08.811.913.050.134.415.500.049]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Circadian Rhythm Signaling Peptides and Proteins [D12.644.128]
CLOCK Proteins [D12.644.128.100]
Proteins [D12.776]
Circadian Rhythm Signaling Peptides and Proteins [D12.776.189]
CLOCK Proteins [D12.776.189.200]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
CLOCK Proteins [D12.776.260.103.562]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
CLOCK Proteins [D12.776.930.125.562]

Below are MeSH descriptors whose meaning is related to "CLOCK Proteins".

Below are MeSH descriptors whose meaning is more specific than "CLOCK Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CLOCK Proteins" by people in this website by year, and whether "CLOCK Proteins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2004 and 2014 and 2017 and 2019 and 2021 and 2023 and 2024

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2004	1	1
2014	1	1
2017	1	1
2019	1	1
2021	1	1
2023	1	1
2024	1	1

Below are the most recent publications written about "CLOCK Proteins" by people in Profiles.

Akpoghiran O, Afonso DJS, Zhang Y, Koh K. TARANIS Interacts with VRILLE and PDP1 to Modulate the Circadian Transcriptional Feedback Mechanism in Drosophila. J Neurosci. 2024 01 31; 44(5).

View in: PubMed
Pelham JF, Mosier AE, Altshuler SC, Rhodes ML, Kirchhoff CL, Fall WB, Mann C, Baik LS, Chiu JC, Hurley JM. Conformational changes in the negative arm of the circadian clock correlate with dynamic interactomes involved in post-transcriptional regulation. Cell Rep. 2023 04 25; 42(4):112376.

View in: PubMed
Mosier AE, Hurley JM. Circadian Interactomics: How Research Into Protein-Protein Interactions Beyond the Core Clock Has Influenced the Model of Circadian Timekeeping. J Biol Rhythms. 2021 08; 36(4):315-328.

View in: PubMed
Koritala BSC, Wager C, Waters JC, Pachucki R, Piccoli B, Feng Y, Scheinfeldt LB, Shende SM, Park S, Hozier JI, Lalakia P, Kumar D, Lee K. Habitat-Specific Clock Variation and Its Consequence on Reproductive Fitness. J Biol Rhythms. 2020 04; 35(2):134-144.

View in: PubMed
Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018 01; 20(1):104-115.

View in: PubMed
Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, Wu MN. WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 2014 Apr 02; 82(1):151-66.

View in: PubMed
Jaramillo AM, Zheng X, Zhou Y, Amado DA, Sheldon A, Sehgal A, Levitan IB. Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neurosci. 2004 Jan 27; 5:3.

View in: PubMed

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