"Aromatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
| Descriptor ID |
D001141
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| MeSH Number(s) |
D08.244.453.489.500 D08.244.453.915.099 D08.811.682.690.708.170.447.500 D08.811.682.690.708.170.915.099 D12.776.422.220.453.489.500 D12.776.422.220.453.915.099
|
| Concept/Terms |
Aromatase- Aromatase
- Estrogen Synthetase
- Estrogen Synthase
- Cytochrome P450 19
- CYP19 Protein
- Protein, CYP19
- Cytochrome P-450(AROM)
- CYP 19
- Cytochrome P-450 CYP19
- Cytochrome P 450 CYP19
- P450AROM
- Androstenedione Aromatase
- Aromatase, Androstenedione
- CYP19
|
Below are MeSH descriptors whose meaning is more general than "Aromatase".
Below are MeSH descriptors whose meaning is more specific than "Aromatase".
This graph shows the total number of publications written about "Aromatase" by people in this website by year, and whether "Aromatase" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Aromatase" by people in Profiles.
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Stearns V, Jegede OA, Chang VT, Skaar TC, Berenberg JL, Nand R, Shafqat A, Jacobs NL, Luginbuhl W, Gilman P, Benson AB, Goodman JR, Buchschacher GL, Henry NL, Loprinzi CL, Flynn PJ, Mitchell EP, Fisch MJ, Sparano JA, Wagner LI. A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11. Clin Cancer Res. 2024 Jul 01; 30(13):2709-2718.
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Henry NL, Chan HP, Dantzer J, Goswami CP, Li L, Skaar TC, Rae JM, Desta Z, Khouri N, Pinsky R, Oesterreich S, Zhou C, Hadjiiski L, Philips S, Robarge J, Nguyen AT, Storniolo AM, Flockhart DA, Hayes DF, Helvie MA, Stearns V. Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects. Br J Cancer. 2013 Oct 29; 109(9):2331-9.
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Sirianni R, Capparelli C, Chimento A, Panza S, Catalano S, Lanzino M, Pezzi V, And? S. Nandrolone and stanozolol upregulate aromatase expression and further increase IGF-I-dependent effects on MCF-7 breast cancer cell proliferation. Mol Cell Endocrinol. 2012 Nov 05; 363(1-2):100-10.
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Hurst BS, Zacur HA, Schlaff WD, Damewood MD, Berkovitz GD. The effect of epidermal growth factor in human granulosa cells varies with follicle size. J Endocrinol Invest. 1993 Feb; 16(2):143-5.
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Hurst BS, Zacur HA, Schlaff WD, Berkovitz GD. Use of granulosa-luteal cell culture to evaluate low and high clinical responses to menotropin stimulation. J Endocrinol Invest. 1992 Sep; 15(8):567-72.
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Polan ML, Daniele A, Russell JB, DeCherney AH. Ovulation induction with human menopausal gonadotropin compared to human urinary follicle-stimulating hormone results in a significant shift in follicular fluid androgen levels without discernible differences in granulosa-luteal cell function. J Clin Endocrinol Metab. 1986 Dec; 63(6):1284-91.
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Polan ML, Laufer N, Ohkawa R, Botero-Ruiz W, Haseltine FP, DeCherney AH, Behrman HR. The association between granulosa cell aromatase activity and oocyte-corona-cumulus-complex maturity from individual human follicles. J Clin Endocrinol Metab. 1984 Jul; 59(1):170-4.