Steroid 17-alpha-Hydroxylase

"Steroid 17-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Descriptor ID	D013254
MeSH Number(s)	D08.244.453.487.500 D08.244.453.915.748 D08.811.682.690.708.170.444.500 D08.811.682.690.708.170.915.748 D12.776.422.220.453.487.500 D12.776.422.220.453.915.748
Concept/Terms	Steroid 17-alpha-Hydroxylase Steroid 17-alpha-Hydroxylase 17-alpha-Hydroxylase, Steroid Steroid 17 alpha-Hydroxylase 17 alpha-Hydroxylase, Steroid Steroid 17 alpha Hydroxylase Steroid-17-Hydroxylase Steroid 17 Hydroxylase Steroid 17-Hydroxylase 17-Hydroxylase, Steroid Steroid 17-Monooxygenase 17-Monooxygenase, Steroid Steroid 17 Monooxygenase 17,20-Desmolase 17,20 Desmolase 17,20-Lyase 17,20 Lyase Cytochrome P450(17 alpha) Steroid 17 alpha-Monooxygenase 17 alpha-Monooxygenase, Steroid Steroid 17 alpha Monooxygenase alpha-Monooxygenase, Steroid 17 CYP17 17 alpha-Hydroxylase 17 alpha Hydroxylase P450(c17) Cytochrome P-450(17-alpha) 17 alpha-Hydroxylase Cytochrome P-450 17 alpha Hydroxylase Cytochrome P 450 Cytochrome P-450(17 alpha) 17 alpha-Hydroxyprogesterone Aldolase 17 alpha-Hydroxyprogesterone Aldolase 17 alpha Hydroxyprogesterone Aldolase Aldolase, 17 alpha-Hydroxyprogesterone alpha-Hydroxyprogesterone Aldolase, 17 Hydroxyprogesterone Aldolase Aldolase, Hydroxyprogesterone

Below are MeSH descriptors whose meaning is more general than "Steroid 17-alpha-Hydroxylase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Cytochrome P450 Family 17 [D08.244.453.487]
Steroid 17-alpha-Hydroxylase [D08.244.453.487.500]
Steroid Hydroxylases [D08.244.453.915]
Steroid 17-alpha-Hydroxylase [D08.244.453.915.748]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Cytochrome P450 Family 17 [D08.811.682.690.708.170.444]
Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.444.500]
Steroid Hydroxylases [D08.811.682.690.708.170.915]
Steroid 17-alpha-Hydroxylase [D08.811.682.690.708.170.915.748]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Cytochrome P450 Family 17 [D12.776.422.220.453.487]
Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.487.500]
Steroid Hydroxylases [D12.776.422.220.453.915]
Steroid 17-alpha-Hydroxylase [D12.776.422.220.453.915.748]

Below are MeSH descriptors whose meaning is related to "Steroid 17-alpha-Hydroxylase".

Below are MeSH descriptors whose meaning is more specific than "Steroid 17-alpha-Hydroxylase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Steroid 17-alpha-Hydroxylase" by people in this website by year, and whether "Steroid 17-alpha-Hydroxylase" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2008	0	1	1
2010	1	0	1
2012	1	1	2
2013	0	1	1
2014	1	0	1
2018	0	1	1
2022	0	1	1

Below are the most recent publications written about "Steroid 17-alpha-Hydroxylase" by people in Profiles.

Tong ZB, Otsuka N, Tu W, Wei Q, DeCherney AH. P450 Side-Chain Cleavage Enzyme (P450-SCC) Is an Ovarian Autoantigen in a Mouse Model for Autoimmune Oophoritis. Reprod Sci. 2022 08; 29(8):2391-2400.

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Gupta S, Nordquist LT, Fleming MT, Berry WR, Zhang J, Ervin SL, Eisner JR, Baskin-Bey ES, Shore ND. Phase I Study of Seviteronel, a Selective CYP17 Lyase and Androgen Receptor Inhibitor, in Men with Castration-Resistant Prostate Cancer. Clin Cancer Res. 2018 11 01; 24(21):5225-5232.

View in: PubMed
Rathkopf DE, Smith MR, de Bono JS, Logothetis CJ, Shore ND, de Souza P, Fizazi K, Mulders PF, Mainwaring P, Hainsworth JD, Beer TM, North S, Fradet Y, Van Poppel H, Carles J, Flaig TW, Efstathiou E, Yu EY, Higano CS, Taplin ME, Griffin TW, Todd MB, Yu MK, Park YC, Kheoh T, Small EJ, Scher HI, Molina A, Ryan CJ, Saad F. Updated interim efficacy analysis and long-term safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients without prior chemotherapy (COU-AA-302). Eur Urol. 2014 Nov; 66(5):815-25.

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Mostaghel EA, Nelson PS, Lange P, Lin DW, Taplin ME, Balk S, Ellis W, Kantoff P, Marck B, Tamae D, Matsumoto AM, True LD, Vessella R, Penning T, Hunter Merrill R, Gulati R, Montgomery B. Targeted androgen pathway suppression in localized prostate cancer: a pilot study. J Clin Oncol. 2014 Jan 20; 32(3):229-37.

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Yoshimoto FK, Zhou Y, Peng HM, Stidd D, Yoshimoto JA, Sharma KK, Matthew S, Auchus RJ. Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates. Biochemistry. 2012 Sep 11; 51(36):7064-77.

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Tolcher AW, Chi KN, Shore ND, Pili R, Molina A, Acharya M, Kheoh T, Jiao JJ, Gonzalez M, Trinh A, Pankras C, Tran N. Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2012 Aug; 70(2):305-13.

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Wright JL, Kwon EM, Lin DW, Kolb S, Koopmeiners JS, Feng Z, Ostrander EA, Stanford JL. CYP17 polymorphisms and prostate cancer outcomes. Prostate. 2010 Jul 01; 70(10):1094-101.

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Johnson KJ, McCahan SM, Si X, Campion L, Herrmann R, Barthold JS. The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure. Toxicol Sci. 2008 Oct; 105(2):360-7.

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Shin MH, Lee KM, Yang JH, Nam SJ, Kim JW, Yoo KY, Park SK, Noh DY, Ahn SH, Kim B, Kang D. Genetic polymorphism of CYP17 and breast cancer risk in Korean women. Exp Mol Med. 2005 Feb 28; 37(1):11-7.

View in: PubMed

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