"Genes, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes encoding the different subunits of the IMMUNOGLOBULINS, for example the IMMUNOGLOBULIN LIGHT CHAIN GENES and the IMMUNOGLOBULIN HEAVY CHAIN GENES. The heavy and light immunoglobulin genes are present as gene segments in the germline cells. The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). The heavy chain germline genes have an additional segment D (diversity).
| Descriptor ID |
D005803
|
| MeSH Number(s) |
G05.360.340.024.340.335 G12.500.299
|
| Concept/Terms |
Genes, Immunoglobulin- Genes, Immunoglobulin
- Immunoglobulin Genes
- Gene, Immunoglobulin
- Immunoglobulin Gene
- Genes, Ig
- Gene, Ig
- Ig Gene
- Ig Genes
|
Below are MeSH descriptors whose meaning is more general than "Genes, Immunoglobulin".
Below are MeSH descriptors whose meaning is more specific than "Genes, Immunoglobulin".
This graph shows the total number of publications written about "Genes, Immunoglobulin" by people in this website by year, and whether "Genes, Immunoglobulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 0 | 3 |
| 1997 | 3 | 1 | 4 |
| 1999 | 2 | 1 | 3 |
| 2000 | 1 | 1 | 2 |
| 2002 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, Immunoglobulin" by people in Profiles.
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Nagalla S, Chou JW, Willingham MC, Ruiz J, Vaughn JP, Dubey P, Lash TL, Hamilton-Dutoit SJ, Bergh J, Sotiriou C, Black MA, Miller LD. Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis. Genome Biol. 2013 Apr 29; 14(4):R34.
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Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol. 2006 Jan 15; 176(2):889-98.
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Bosma GC, Kim J, Urich T, Fath DM, Cotticelli MG, Ruetsch NR, Radic MZ, Bosma MJ. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J Exp Med. 2002 Dec 02; 196(11):1483-95.
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Alabyev B, Manser T. Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice. J Immunol. 2002 Oct 01; 169(7):3819-24.
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Lasota J, Nordling S, Miettinen M. Testicular diffuse large cell lymphoma with tubule preservation--molecular genetic evidence of transformation from previous follicular lymphoma. Virchows Arch. 2000 Mar; 436(3):276-83.
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Hsueh RC, Scheuermann RH. Tyrosine kinase activation in the decision between growth, differentiation, and death responses initiated from the B cell antigen receptor. Adv Immunol. 2000; 75:283-316.
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Vora KA, Tumas-Brundage K, Manser T. Contrasting the in situ behavior of a memory B cell clone during primary and secondary immune responses. J Immunol. 1999 Oct 15; 163(8):4315-27.
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Raschke EE, Albert T, Eick D. Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II. J Immunol. 1999 Oct 15; 163(8):4375-82.
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Webb C, Zong RT, Lin D, Wang Z, Kaplan M, Paulin Y, Smith E, Probst L, Bryant J, Goldstein A, Scheuermann R, Tucker P. Differential regulation of immunoglobulin gene transcription via nuclear matrix-associated regions. Cold Spring Harb Symp Quant Biol. 1999; 64:109-18.
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Vora KA, Ravetch JV, Manser T. Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response. J Immunol. 1997 Sep 01; 159(5):2116-24.