"Genes, Lethal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Descriptor ID |
D005804
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MeSH Number(s) |
G05.360.340.024.340.350
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genes, Lethal".
Below are MeSH descriptors whose meaning is more specific than "Genes, Lethal".
This graph shows the total number of publications written about "Genes, Lethal" by people in this website by year, and whether "Genes, Lethal" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 0 | 1 | 1 |
2007 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2020 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Genes, Lethal" by people in Profiles.
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Tripolszki K, Sasaki E, Hotakainen R, Kassim AH, Pereira C, Rolfs A, Bauer P, Reardon W, Bertoli-Avella AM. An X-linked syndrome with severe neurodevelopmental delay, hydrocephalus, and early lethality caused by a missense variation in the OTUD5 gene. Clin Genet. 2021 02; 99(2):303-308.
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Bull JJ, Joyce P, Gladstone E, Molineux IJ. Empirical complexities in the genetic foundations of lethal mutagenesis. Genetics. 2013 Oct; 195(2):541-52.
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Arakawa H, Bednar T, Wang M, Paul K, Mladenov E, Bencsik-Theilen AA, Iliakis G. Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells. Nucleic Acids Res. 2012 Mar; 40(6):2599-610.
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Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B. SCCRO promotes glioma formation and malignant progression in mice. Neoplasia. 2010 Jun; 12(6):476-84.
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Astrof S, Crowley D, Hynes RO. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol. 2007 Nov 1; 311(1):11-24.
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Bailis AM, Maines S, Negritto MT. The essential helicase gene RAD3 suppresses short-sequence recombination in Saccharomyces cerevisiae. Mol Cell Biol. 1995 Aug; 15(8):3998-4008.
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Radice G, Lee JJ, Costantini F. H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Development. 1991 Mar; 111(3):801-11.
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Costantini F, Radice G, Lee JL, Chada KK, Perry W, Son HJ. Insertional mutations in transgenic mice. Prog Nucleic Acid Res Mol Biol. 1989; 36:159-69.