Immunoglobulin Joining Region
"Immunoglobulin Joining Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
| Descriptor ID |
D007133
|
| MeSH Number(s) |
D12.644.541.500.650.500.590 D12.776.124.486.485.680.650.500.590 D12.776.124.486.485.797.590 D12.776.124.790.651.680.650.500.590 D12.776.124.790.651.797.590 D12.776.377.715.548.680.650.500.590 D12.776.377.715.548.797.590
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Joining Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Joining Region".
This graph shows the total number of publications written about "Immunoglobulin Joining Region" by people in this website by year, and whether "Immunoglobulin Joining Region" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Immunoglobulin Joining Region" by people in Profiles.
-
Ruetsch NR, Bosma GC, Bosma MJ. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. J Exp Med. 2000 Jun 05; 191(11):1933-43.
-
Chang Y, Bosma GC, Bosma MJ. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity. 1995 Jun; 2(6):607-16.
-
Schwaber J, Malone B. Germ line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ. J Clin Invest. 1992 Jun; 89(6):2046-52.
-
Kim MG, Schuler W, Bosma MJ, Marcu KB. Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice. J Immunol. 1988 Aug 15; 141(4):1341-7.