Insulin

"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Descriptor ID	D007328
MeSH Number(s)	D06.472.699.587.200.500.625 D12.644.548.586.200.500.625
Concept/Terms	Insulin Insulin Insulin, Regular Regular Insulin Soluble Insulin Insulin, Soluble Insulin A Chain Insulin A Chain Sodium Insulin Sodium Insulin Insulin, Sodium Novolin Novolin Iletin Iletin Insulin B Chain Insulin B Chain Chain, Insulin B

Below are MeSH descriptors whose meaning is more general than "Insulin".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Pancreatic Hormones [D06.472.699.587]
Insulins [D06.472.699.587.200]
Proinsulin [D06.472.699.587.200.500]
Insulin [D06.472.699.587.200.500.625]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Hormones [D12.644.548]
Pancreatic Hormones [D12.644.548.586]
Insulins [D12.644.548.586.200]
Proinsulin [D12.644.548.586.200.500]
Insulin [D12.644.548.586.200.500.625]

Below are MeSH descriptors whose meaning is related to "Insulin".

Below are MeSH descriptors whose meaning is more specific than "Insulin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Insulin" by people in this website by year, and whether "Insulin" was a major or minor topic of these publications.

Bar chart showing 84 publications over 24 distinct years, with a maximum of 10 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
1997	0	1	1
1999	0	1	1
2000	0	1	1
2001	1	2	3
2002	2	1	3
2003	1	3	4
2004	1	3	4
2005	4	2	6
2006	1	5	6
2007	1	4	5
2008	4	2	6
2009	2	7	9
2010	4	2	6
2011	3	7	10
2012	3	1	4
2013	1	3	4
2014	1	1	2
2015	1	0	1
2016	0	1	1
2017	1	0	1
2018	0	1	1
2019	0	2	2
2021	2	0	2

Below are the most recent publications written about "Insulin" by people in Profiles.

Vella V, Giuliano M, Nicolosi ML, Majorana MG, Marc MA, Muoio MG, Morrione A, Maggiolini M, Lappano R, De Francesco EM, Belfiore A. DDR1 Affects Metabolic Reprogramming in Breast Cancer Cells by Cross-Talking to the Insulin/IGF System. Biomolecules. 2021 06 22; 11(7).

View in: PubMed
Evans L, London JW, Palchuk MB. Assessing real-world medication data completeness. J Biomed Inform. 2021 07; 119:103847.

View in: PubMed
Ostan R, Monti D, Mari D, Arosio B, Gentilini D, Ferri E, Passarino G, De Rango F, D'Aquila P, Mariotti S, Pasquali R, Fanelli F, Bucci L, Franceschi C, Vitale G. Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality. J Gerontol A Biol Sci Med Sci. 2019 05 16; 74(6):802-810.

View in: PubMed
Xiao D, Zhu L, Edirisinghe I, Fareed J, Brailovsky Y, Burton-Freeman B. Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial. Obesity (Silver Spring). 2019 04; 27(4):542-550.

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Mathieu C, Dandona P, Gillard P, Senior P, Hasslacher C, Araki E, Lind M, Bain SC, Jabbour S, Arya N, Hansen L, Thorén F, Langkilde AM. Efficacy and Safety of Dapagliflozin in Patients With Inadequately Controlled Type 1 Diabetes (the DEPICT-2 Study): 24-Week Results From a Randomized Controlled Trial. Diabetes Care. 2018 09; 41(9):1938-1946.

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Daniel R, Villuri S, Furlong K. Management of hyperglycemia in the neurosurgery patient. Hosp Pract (1995). 2017 Oct; 45(4):150-157.

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Palmieri EM, Menga A, Lebrun A, Hooper DC, Butterfield DA, Mazzone M, Castegna A. Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells. Antioxid Redox Signal. 2017 03 10; 26(8):351-363.

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Winters B, Plymate S, Zeliadt SB, Holt S, Zhang X, Hu E, Lin DW, Morrissey C, Wooldridge B, Gore JL, Porter MP, Wright JL. Metformin effects on biochemical recurrence and metabolic signaling in the prostate. Prostate. 2015 Nov; 75(15):1694-703.

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Riddle RC, Frey JL, Tomlinson RE, Ferron M, Li Y, DiGirolamo DJ, Faugere MC, Hussain MA, Karsenty G, Clemens TL. Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Mol Cell Biol. 2014 May; 34(10):1850-62.

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Chow F, Gong Y, Lippa CF. The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition. Am J Alzheimers Dis Other Demen. 2014 Jun; 29(4):303-10.

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