Phenobarbital

"Phenobarbital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.

Descriptor ID	D010634
MeSH Number(s)	D03.383.742.698.253.650
Concept/Terms	Phenobarbital Phenobarbital Phenylbarbital Phenylethylbarbituric Acid Acid, Phenylethylbarbituric Phenemal Phenobarbitone Hysteps Hysteps Phenobarbital Sodium Phenobarbital Sodium Sodium, Phenobarbital Phenobarbital, Monosodium Salt Monosodium Salt Phenobarbital Luminal Luminal Gardenal Gardenal

Below are MeSH descriptors whose meaning is more general than "Phenobarbital".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Pyrimidinones [D03.383.742.698]
Barbiturates [D03.383.742.698.253]
Phenobarbital [D03.383.742.698.253.650]

Below are MeSH descriptors whose meaning is related to "Phenobarbital".

Below are MeSH descriptors whose meaning is more specific than "Phenobarbital".

Phenobarbital
Primidone

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phenobarbital" by people in this website by year, and whether "Phenobarbital" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2020 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2010	0	1	1
2012	0	1	1
2013	1	0	1
2017	0	1	1
2019	0	1	1
2020	1	1	2
2022	0	2	2
2024	0	1	1

Below are the most recent publications written about "Phenobarbital" by people in Profiles.

Anbalagan S, Anderson V, Favara MT, Stark D, Carola D, Solarin K, Adeniyi-Jones S, Kraft WK, Aghai ZH. Buprenorphine vs. morphine: impact on neonatal opioid withdrawal syndrome (NOWS) outcomes in a single center retrospective study. J Perinatol. 2025 Apr; 45(4):473-479.

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Peltz G, Jansson LM, Adeniyi-Jones S, Cohane C, Drover D, Shafer S, Wang M, Wu M, Govindaswami B, Jegatheesan P, Argani C, Khan S, Kraft WK. Ondansetron to reduce neonatal opioid withdrawal severity a randomized clinical trial. J Perinatol. 2023 03; 43(3):271-276.

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Friedman D, Zubair N, Favara MT, Lafferty M, Carola D, Adeniyi-Jones S, Solarin K, Aghai ZH. Do small for gestational age infants have less severe neonatal abstinence syndrome? J Neonatal Perinatal Med. 2022; 15(4):753-758.

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Smith J, Lafferty M, Boelig RC, Carola D, Adeniyi-Jones S, Kraft WK, Greenspan JS, Aghai ZH. Is Maternal Methadone Dose Associated with the Severity of Neonatal Abstinence Syndrome? Am J Perinatol. 2022 07; 39(10):1138-1144.

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Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, Kuperman R, Harbert MJ, Michelson D, Joe P, Wang S, Rismanchi N, Le NM, Mower A, Kim J, Battin MR, Lane B, Honold J, Knodel E, Arnell K, Bridge R, Lee L, Ernstrom K, Raman R, Haas RH. Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. Pediatrics. 2020 06; 145(6).

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Jones HE, Kraft WK. Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome. Clin Perinatol. 2019 06; 46(2):349-366.

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Kraft WK, Adeniyi-Jones SC, Chervoneva I, Greenspan JS, Abatemarco D, Kaltenbach K, Ehrlich ME. Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome. N Engl J Med. 2017 06 15; 376(24):2341-2348.

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Maitre NL, Smolinsky C, Slaughter JC, Stark AR. Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. J Perinatol. 2013 Nov; 33(11):841-6.

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Vendrame M, Guilhoto LM, Loddenkemper T, Gregas M, Bourgeois BF, Kothare SV. Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience. Pediatr Neurol. 2012 May; 46(5):276-80.

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Kraft WK, Dysart K, Greenspan JS, Gibson E, Kaltenbach K, Ehrlich ME. Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome. Addiction. 2011 Mar; 106(3):574-80.

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