Poly Adenosine Diphosphate Ribose

"Poly Adenosine Diphosphate Ribose" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES.

Descriptor ID	D011064
MeSH Number(s)	D09.408.620.569.070.125.600 D13.695.578.550.530 D13.695.827.708.070.125.600
Concept/Terms	Poly Adenosine Diphosphate Ribose Poly Adenosine Diphosphate Ribose Poly-ADPR Poly ADPR Poly(ADP-Ribose) Poly-Adenosine Diphosphate-Ribose Diphosphate-Ribose, Poly-Adenosine Poly ADP Ribose ADP Ribose, Poly Ribose, Poly ADP

Below are MeSH descriptors whose meaning is more general than "Poly Adenosine Diphosphate Ribose".

Chemicals and Drugs [D]
Carbohydrates [D09]
Glycosides [D09.408]
Nucleotides [D09.408.620]
Nucleoside Diphosphate Sugars [D09.408.620.569]
Adenosine Diphosphate Sugars [D09.408.620.569.070]
Adenosine Diphosphate Ribose [D09.408.620.569.070.125]
Poly Adenosine Diphosphate Ribose [D09.408.620.569.070.125.600]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleotides [D13.695]
Polynucleotides [D13.695.578]
Polyribonucleotides [D13.695.578.550]
Poly Adenosine Diphosphate Ribose [D13.695.578.550.530]
Ribonucleotides [D13.695.827]
Nucleoside Diphosphate Sugars [D13.695.827.708]
Adenosine Diphosphate Sugars [D13.695.827.708.070]
Adenosine Diphosphate Ribose [D13.695.827.708.070.125]
Poly Adenosine Diphosphate Ribose [D13.695.827.708.070.125.600]

Below are MeSH descriptors whose meaning is related to "Poly Adenosine Diphosphate Ribose".

Below are MeSH descriptors whose meaning is more specific than "Poly Adenosine Diphosphate Ribose".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Poly Adenosine Diphosphate Ribose" by people in this website by year, and whether "Poly Adenosine Diphosphate Ribose" was a major or minor topic of these publications.

Bar chart showing 19 publications over 11 distinct years, with a maximum of 3 publications in 2013 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	1	1	2
2011	1	0	1
2012	1	0	1
2013	3	0	3
2014	1	1	2
2015	2	0	2
2020	1	0	1
2022	1	2	3
2023	1	0	1
2024	1	1	2
2025	1	0	1

Below are the most recent publications written about "Poly Adenosine Diphosphate Ribose" by people in Profiles.

Cheng SJ, Gafaar T, Kuttiyatveetil JRA, Sverzhinsky A, Chen C, Xu M, Lilley A, Pascal JM, Leung AKL. Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13. Nat Commun. 2025 Jan 13; 16(1):621.

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Langelier MF, Mirhasan M, Gilbert K, Sverzhinksy A, Furtos A, Pascal JM. PARP enzyme de novo synthesis of protein-free poly(ADP-ribose). Mol Cell. 2024 Dec 19; 84(24):4758-4773.e6.

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Vekariya U, Minakhin L, Chandramouly G, Tyagi M, Kent T, Sullivan-Reed K, Atkins J, Ralph D, Nieborowska-Skorska M, Kukuyan AM, Tang HY, Pomerantz RT, Skorski T. PARG is essential for Pol?-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nat Commun. 2024 Jul 11; 15(1):5822.

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Frigon L, Pascal JM. Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Res. 2023 12 11; 51(22):12492-12507.

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Kuttiyatveetil JRA, Soufari H, Dasovich M, Uribe IR, Mirhasan M, Cheng SJ, Leung AKL, Pascal JM. Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose). Cell Rep. 2022 10 25; 41(4):111529.

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Gao J, Mewborne QT, Girdhar A, Sheth U, Coyne AN, Punathil R, Kang BG, Dasovich M, Veire A, DeJesus Hernandez M, Liu S, Shi Z, Dafinca R, Fouquerel E, Talbot K, Kam TI, Zhang YJ, Dickson D, Petrucelli L, van Blitterswijk M, Guo L, Dawson TM, Dawson VL, Leung AKL, Lloyd TE, Gendron TF, Rothstein JD, Zhang K. Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins. Sci Transl Med. 2022 09 14; 14(662):eabq3215.

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Rouleau-Turcotte ?, Krastev DB, Pettitt SJ, Lord CJ, Pascal JM. Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol Cell. 2022 08 18; 82(16):2939-2951.e5.

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Rouleau-Turcotte ?, Pascal JM. Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin. Mol Cell. 2020 11 19; 80(4):560-561.

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Pascal JM, Ellenberger T. The rise and fall of poly(ADP-ribose): An enzymatic perspective. DNA Repair (Amst). 2015 Aug; 32:10-16.

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Gagn? JP, Ethier C, Defoy D, Bourassa S, Langelier MF, Riccio AA, Pascal JM, Moon KM, Foster LJ, Ning Z, Figeys D, Droit A, Poirier GG. Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs. DNA Repair (Amst). 2015 Jun; 30:68-79.

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