Ahmed Chahdi

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentHematology
Address1020 Locust St.
Philadelphia PA 19107
Phone414-456-4438
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cheng K, Larabee SM, Tolaymat M, Hanscom M, Shang AC, Schledwitz A, Hu S, Drachenberg CB, Zhan M, Chahdi A, Raufman JP. Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, ßPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice. Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G627-G643. PMID: 33566751.
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    2. Said AH, Hu S, Abutaleb A, Watkins T, Cheng K, Chahdi A, Kuppusamy P, Saxena N, Xie G, Raufman JP. Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochem J. 2017 Feb 20; 474(5):647-665. PMID: 28008134.
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    3. Chahdi A, Raufman JP. The Cdc42/Rac nucleotide exchange factor protein ß1Pix (Pak-interacting exchange factor) modulates ß-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of ß1PIX with ß-catenin. J Biol Chem. 2013 Nov 22; 288(47):34019-29. PMID: 24129564.
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    4. Raufman JP, Cheng K, Saxena N, Chahdi A, Belo A, Khurana S, Xie G. Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells. Biochem Biophys Res Commun. 2011 Nov 18; 415(2):319-24. PMID: 22027145.
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    5. Belo A, Cheng K, Chahdi A, Shant J, Xie G, Khurana S, Raufman JP. Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. Am J Physiol Gastrointest Liver Physiol. 2011 May; 300(5):G749-60. PMID: 21273532.
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    6. Pavlov TS, Chahdi A, Ilatovskaya DV, Levchenko V, Vandewalle A, Pochynyuk O, Sorokin A, Staruschenko A. Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol. 2010 May; 21(5):833-43. PMID: 20338996.
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    7. Chahdi A, Sorokin A. The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1330-5. PMID: 20026011.
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    8. Chahdi A, Sorokin A. Endothelin-1 induces p66Shc activation through EGF receptor transactivation: Role of beta(1)Pix/Galpha(i3) interaction. Cell Signal. 2010 Feb; 22(2):325-9. PMID: 19804820.
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    9. Chahdi A, Sorokin A. Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell. 2008 Jun; 19(6):2609-19. PMID: 18385518.
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    10. Chahdi A, Sorokin A. Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol. 2008 Mar; 28(5):1679-87. PMID: 18160719.
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    11. Chahdi A, Sorokin A. Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway. Exp Biol Med (Maywood). 2006 Jun; 231(6):761-5. PMID: 16740995.
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    12. Chahdi A, Miller B, Sorokin A. Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J Biol Chem. 2005 Jan 7; 280(1):578-84. PMID: 15513924.
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    13. Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, Beaven MA. Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol. 2004 Aug; 24(16):6980-92. PMID: 15282299.
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    14. Chahdi A, Sorokin A, Dunn MJ, Landry Y. The Rac/Cdc42 guanine nucleotide exchange factor beta1Pix enhances mastoparan-activated Gi-dependent pathway in mast cells. Biochem Biophys Res Commun. 2004 Apr 30; 317(2):384-9. PMID: 15063769.
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    15. Chahdi A, Choi WS, Kim YM, Beaven MA. Mastoparan selectively activates phospholipase D2 in cell membranes. J Biol Chem. 2003 Apr 4; 278(14):12039-45. PMID: 12556526.
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    16. Chahdi A, Choi WS, Kim YM, Fraundorfer PF, Beaven MA. Serine/threonine protein kinases synergistically regulate phospholipase D1 and 2 and secretion in RBL-2H3 mast cells. Mol Immunol. 2002 Sep; 38(16-18):1269-76. PMID: 12217394.
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    17. Choi WS, Chahdi A, Kim YM, Fraundorfer PF, Beaven MA. Regulation of phospholipase D and secretion in mast cells by protein kinase A and other protein kinases. Ann N Y Acad Sci. 2002 Jun; 968:198-212. PMID: 12119277.
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