"Protein Phosphatase 2C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
Descriptor ID |
D000071636
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MeSH Number(s) |
D08.811.277.352.650.625.716
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Concept/Terms |
Protein Phosphatase 2C- Protein Phosphatase 2C
- 2C, Protein Phosphatase
- Phosphatase 2C, Protein
- PPM1 Protein Phosphatases
- Phosphatases, PPM1 Protein
- Protein Phosphatases, PPM1
- Ptc2 Phosphatase
- Phosphatase, Ptc2
- PPM1 Magnesium-Dependent Protein Phosphatases
- PPM1 Magnesium Dependent Protein Phosphatases
Protein Phosphatase 2C delta- Protein Phosphatase 2C delta
- Protein Phosphatase 1D Magnesium-Dependent, delta isoform
- Protein Phosphatase 1D Magnesium Dependent, delta isoform
- PPM1D Phosphatase
- Phosphatase, PPM1D
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Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2C".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2C".
This graph shows the total number of publications written about "Protein Phosphatase 2C" by people in this website by year, and whether "Protein Phosphatase 2C" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Phosphatase 2C" by people in Profiles.
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Stickles XB, Marchion DC, Bicaku E, Al Sawah E, Abbasi F, Xiong Y, Bou Zgheib N, Boac BM, Orr BC, Judson PL, Berry A, Hakam A, Wenham RM, Apte SM, Berglund AE, Lancaster JM. BAD-mediated apoptotic pathway is associated with human cancer development. Int J Mol Med. 2015 Apr; 35(4):1081-7.