"Fibrillins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of extracellular matrix glycoproteins that is structurally similar to LATENT TGF-BETA BINDING PROTEINS, but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. Fibrillins assemble into 10-12 nm MICROFIBRILS that function in a variety of cell interactions with the EXTRACELLULAR MATRIX and developmental processes such as ELASTIC TISSUE maintenance and assembly, and the targeting of growth factors to the extracellular matrix.
| Descriptor ID |
D000071837
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| MeSH Number(s) |
D09.400.430.875 D12.776.395.341 D12.776.860.300.400
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Fibrillins".
Below are MeSH descriptors whose meaning is more specific than "Fibrillins".
This graph shows the total number of publications written about "Fibrillins" by people in this website by year, and whether "Fibrillins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibrillins" by people in Profiles.
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Zhang L, Lai YH, Capasso JE, Han S, Levin AV. Early onset ectopia lentis due to a FBN1 mutation with non-penetrance. Am J Med Genet A. 2015 Jun; 167(6):1365-8.
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Teekakirikul P, Milewicz DM, Miller DT, Lacro RV, Regalado ES, Rosales AM, Ryan DP, Toler TL, Lin AE. Thoracic aortic disease in two patients with juvenile polyposis syndrome and SMAD4 mutations. Am J Med Genet A. 2013 Jan; 161A(1):185-91.
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Jiménez SA, Rosenbloom J. Angiotensin II blockade in Marfan's syndrome. N Engl J Med. 2008 Oct 16; 359(16):1732-3; author reply 1733-4.
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Hartner A, Schaefer L, Porst M, Cordasic N, Gabriel A, Klanke B, Reinhardt DP, Hilgers KF. Role of fibrillin-1 in hypertensive and diabetic glomerular disease. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1329-36.
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Fedak PW, de Sa MP, Verma S, Nili N, Kazemian P, Butany J, Strauss BH, Weisel RD, David TE. Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. J Thorac Cardiovasc Surg. 2003 Sep; 126(3):797-806.
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Kirsch AJ, Macarak EJ, Chaqour B, Quinn T, Zderic S, Flake A, Crombleholme T, Adzick NS, Canning D, Hubbard AM, Rosenbloom J, Snyder HM, Howard PS. Molecular response of the bladder to obstruction. Adv Exp Med Biol. 2003; 539(Pt A):195-216.