"Beclin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
| Descriptor ID |
D000071186
|
| MeSH Number(s) |
D12.644.360.075.335 D12.776.094.500 D12.776.476.075.335
|
| Concept/Terms |
Beclin-1- Beclin-1
- Beclin 1
- Beclin-1 Protein
- Beclin 1 Protein
- GT197 Protein
- ATG-6 Protein
- ATG 6 Protein
- Coiled-coil Myosin-like Bcl2-interacting Protein
- Coiled coil Myosin like Bcl2 interacting Protein
- Beclin1
- ATG6 Protein
|
Below are MeSH descriptors whose meaning is more general than "Beclin-1".
Below are MeSH descriptors whose meaning is more specific than "Beclin-1".
This graph shows the total number of publications written about "Beclin-1" by people in this website by year, and whether "Beclin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Beclin-1" by people in Profiles.
-
Curr? M, Visalli G, Pellican? GF, Ferlazzo N, Costanzo MG, D'Andrea F, Caccamo D, Nunnari G, Ientile R. Vitamin D Status Modulates Inflammatory Response in HIV+ Subjects: Evidence for Involvement of Autophagy and TG2 Expression in PBMC. Int J Mol Sci. 2020 Oct 13; 21(20).
-
Torres A, Gubbiotti MA, Iozzo RV. Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis. J Biol Chem. 2017 Mar 24; 292(12):5055-5069.
-
Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK. Role of the Exocyst Complex Component Sec6/8 in Genomic Stability. Mol Cell Biol. 2015 Nov; 35(21):3633-45.
-
Selvakumaran M, Amaravadi RK, Vasilevskaya IA, O'Dwyer PJ. Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. Clin Cancer Res. 2013 Jun 01; 19(11):2995-3007.
-
DiPaola RS, Dvorzhinski D, Thalasila A, Garikapaty V, Doram D, May M, Bray K, Mathew R, Beaudoin B, Karp C, Stein M, Foran DJ, White E. Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate. 2008 Dec 01; 68(16):1743-52.