von Willebrand Factor

"von Willebrand Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Descriptor ID	D014841
MeSH Number(s)	D12.776.124.125.920 D23.119.985
Concept/Terms	von Willebrand Factor von Willebrand Factor Factor VIIIR-Ag Factor VIIIR Ag Factor VIIIR-RCo Factor VIIIR RCo Ristocetin-Willebrand Factor Ristocetin Willebrand Factor von Willebrand Protein Factor VIII-Related Antigen Factor VIII Related Antigen Ristocetin Cofactor Plasma Factor VIII Complex Plasma Factor VIII Complex

Below are MeSH descriptors whose meaning is more general than "von Willebrand Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Blood Coagulation Factors [D12.776.124.125]
von Willebrand Factor [D12.776.124.125.920]
Biological Factors [D23]
Blood Coagulation Factors [D23.119]
von Willebrand Factor [D23.119.985]

Below are MeSH descriptors whose meaning is more specific than "von Willebrand Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "von Willebrand Factor" by people in this website by year, and whether "von Willebrand Factor" was a major or minor topic of these publications.

Bar chart showing 41 publications over 20 distinct years, with a maximum of 5 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	2	0	2
1999	1	0	1
2000	0	1	1
2001	0	3	3
2002	0	4	4
2003	0	1	1
2005	0	1	1
2006	1	1	2
2007	2	0	2
2008	1	1	2
2009	3	2	5
2010	0	1	1
2014	1	1	2
2016	1	1	2
2017	0	2	2
2018	1	3	4
2019	0	1	1
2021	0	1	1
2022	0	3	3

Below are the most recent publications written about "von Willebrand Factor" by people in Profiles.

Jalagadugula G, Mao G, Goldfinger LE, Wurtzel J, Del Carpio-Cano F, Lambert MP, Estevez B, French DL, Poncz M, Rao AK. Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency. Blood Adv. 2022 09 13; 6(17):5100-5112.

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Mereuta OM, Abbasi M, Arturo Larco JL, Dai D, Liu Y, Arul S, Kadirvel R, Hanel RA, Yoo AJ, Almekhlafi MA, Layton KF, Delgado Almandoz JE, Kvamme P, Mendes Pereira V, Jahromi BS, Nogueira RG, Gounis MJ, Patel B, Aghaebrahim A, Sauvageau E, Bhuva P, Soomro J, Demchuk AM, Thacker IC, Kayan Y, Copelan A, Nazari P, Cantrell DR, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Puri AS, Entwistle J, Meves A, Savastano L, Cloft HJ, Nimjee SM, McBane RD, Kallmes DF, Brinjikji W. Correlation of von Willebrand factor and platelets with acute ischemic stroke etiology and revascularization outcome: an immunohistochemical study. J Neurointerv Surg. 2023 May; 15(5):488-494.

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Hennessy-Strahs S, Kang J, Krause E, Dowling RD, Rame JE, Bartoli CR. Patient-specific severity of von Willebrand factor degradation identifies patients with a left ventricular assist device at high risk for bleeding. J Thorac Cardiovasc Surg. 2024 01; 167(1):196-204.

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Pierce-Williams RAM, Makhamreh MM, Blakey-Cheung S, Gao Z, Al-Kouatly HB. Postpartum Hemorrhage in Patients with Type 1 von Willebrand Disease: A Systematic Review. Semin Thromb Hemost. 2022 Mar; 48(2):219-228.

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Adili R, Holinstat M. Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1817-1830.

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Tilburg J, Adili R, Nair TS, Hawley ME, Tuk DC, Jackson M, Spronk HM, Versteeg HH, Carey TE, van Vlijmen BJM, Maracle CX, Holinstat M. Characterization of hemostasis in mice lacking the novel thrombosis susceptibility gene Slc44a2. Thromb Res. 2018 11; 171:155-159.

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Verbree-Willemsen L, Zhang YN, Gijsberts CM, Schoneveld AH, Wang JW, Lam CSP, Vernooij F, Bots ML, Peelen LM, Grobbee DE, Raichlen JS, de Kleijn DPV. LDL extracellular vesicle coagulation protein levels change after initiation of statin therapy. Findings from the METEOR trial. Int J Cardiol. 2018 Nov 15; 271:247-253.

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Favaloro EJ, Bonar R, Hollestelle MJ, Jennings I, Mohammed S, Meijer P, Woods T, Meiring M. Differential sensitivity of von Willebrand factor activity assays to reduced VWF molecular weight forms: A large international cross-laboratory study. Thromb Res. 2018 06; 166:96-105.

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Jalagadugula G, Goldfinger LE, Mao G, Lambert MP, Rao AK. Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor. Blood Adv. 2018 04 10; 2(7):797-806.

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Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 09; 18(6).

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