"Neprilysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
| Descriptor ID |
D015260
|
| MeSH Number(s) |
D08.811.277.656.300.480.600 D08.811.277.656.675.374.600 D23.050.285.550 D23.101.140.500
|
| Concept/Terms |
Neprilysin- Neprilysin
- CALLA Antigen
- Enkephalinase
- Enkephalinase-24.11
- Enkephalinase 24.11
- Kidney-Brush-Border Neutral Proteinase
- Kidney Brush Border Neutral Proteinase
- Neutral Proteinase, Kidney-Brush-Border
- Membrane Metallo-Endopeptidase
- Membrane Metallo Endopeptidase
- Metallo-Endopeptidase, Membrane
- Neutral Endopeptidase
- Endopeptidase, Neutral
- Neutral Endopeptidase 24.11
- Endopeptidase 24.11, Neutral
- Thermolysin-Like Metalloendopeptidase
- Metalloendopeptidase, Thermolysin-Like
- Thermolysin Like Metalloendopeptidase
- YGG-Forming Enzyme
- Enzyme, YGG-Forming
- YGG Forming Enzyme
- Common Acute Lymphoblastic Leukemia Antigens
- Antigens, Leukemia, Common Acute Lymphoblastic
- Atriopeptidase
- CD10 Antigen
- Antigen, CD10
- Antigens, CD10
- CD10 Antigens
- Endopeptidase-24.11
- Endopeptidase 24.11
- Enkephalin Dipeptidyl Carboxypeptidase
- Carboxypeptidase, Enkephalin Dipeptidyl
- Dipeptidyl Carboxypeptidase, Enkephalin
|
Below are MeSH descriptors whose meaning is more general than "Neprilysin".
Below are MeSH descriptors whose meaning is more specific than "Neprilysin".
This graph shows the total number of publications written about "Neprilysin" by people in this website by year, and whether "Neprilysin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Neprilysin" by people in Profiles.
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Rajapreyar I, Samson R, Ennezat PV, Jemtel THL. Targeted Mono-Therapy for Newly Diagnosed Dilated Cardiomyopathy. J Card Fail. 2019 Aug; 25(8):686-689.
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Feldman AM, Haller JA, DeKosky ST. Valsartan/Sacubitril for Heart Failure: Reconciling Disparities Between Preclinical and Clinical Investigations. JAMA. 2016 Jan 05; 315(1):25-6.
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Witkiewicz AK, Freydin B, Chervoneva I, Potoczek M, Rizzo W, Rui H, Brody JR, Schwartz GF, Lisanti MP. Stromal CD10 and SPARC expression in ductal carcinoma in situ (DCIS) patients predicts disease recurrence. Cancer Biol Ther. 2010 Aug; 10(4):391-6.
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Miettinen M, Dow N, Lasota J, Sobin LH. A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young adults ("gastroblastoma"): a series of 3 cases. Am J Surg Pathol. 2009 Sep; 33(9):1370-7.
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Iijima-Ando K, Hearn SA, Granger L, Shenton C, Gatt A, Chiang HC, Hakker I, Zhong Y, Iijima K. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. J Biol Chem. 2008 Jul 4; 283(27):19066-76.
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Sevilla DW, Gong JZ, Goodman BK, Buckley PJ, Rosoff P, Gockerman JP, Lagoo AS. Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation. Am J Clin Pathol. 2007 Dec; 128(6):981-91.
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Magro CM, Seilstad KH, Porcu P, Morrison CD. Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement. Am J Clin Pathol. 2006 Jul; 126(1):14-22.
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Liao WC, Vesterqvist O, Delaney C, Jemal M, Ferreira I, Ford N, Swanson B, Uderman H. Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor, omapatrilat in healthy subjects. Br J Clin Pharmacol. 2003 Oct; 56(4):395-406.
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Laskin WB, Miettinen M. Epithelioid sarcoma: new insights based on an extended immunohistochemical analysis. Arch Pathol Lab Med. 2003 Sep; 127(9):1161-8.