Proliferating Cell Nuclear Antigen

"Proliferating Cell Nuclear Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

Descriptor ID	D018809
MeSH Number(s)	D12.776.660.740 D23.050.290.750 D23.101.140.600
Concept/Terms	Proliferating Cell Nuclear Antigen Proliferating Cell Nuclear Antigen PCNA Antigen, Proliferating Cell Nuclear

Below are MeSH descriptors whose meaning is more general than "Proliferating Cell Nuclear Antigen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nuclear Proteins [D12.776.660]
Proliferating Cell Nuclear Antigen [D12.776.660.740]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Nuclear [D23.050.290]
Proliferating Cell Nuclear Antigen [D23.050.290.750]
Biomarkers [D23.101]
Biomarkers, Tumor [D23.101.140]
Proliferating Cell Nuclear Antigen [D23.101.140.600]

Below are MeSH descriptors whose meaning is related to "Proliferating Cell Nuclear Antigen".

Below are MeSH descriptors whose meaning is more specific than "Proliferating Cell Nuclear Antigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proliferating Cell Nuclear Antigen" by people in this website by year, and whether "Proliferating Cell Nuclear Antigen" was a major or minor topic of these publications.

Bar chart showing 26 publications over 16 distinct years, with a maximum of 4 publications in 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	1	2
2001	0	1	1
2006	1	3	4
2007	1	1	2
2008	0	2	2
2009	1	0	1
2010	0	1	1
2011	1	0	1
2012	0	1	1
2013	0	1	1
2018	0	1	1
2019	1	2	3
2020	1	0	1
2021	0	1	1
2022	0	2	2
2023	0	2	2

Below are the most recent publications written about "Proliferating Cell Nuclear Antigen" by people in Profiles.

Phadte AS, Bhatia M, Ebert H, Abdullah H, Elrazaq EA, Komolov KE, Pluciennik A. FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2302103120.

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Fenstermaker TK, Petruk S, Kovermann SK, Brock HW, Mazo A. RNA polymerase II associates with active genes during DNA replication. Nature. 2023 08; 620(7973):426-433.

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Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden KLB, Omichinski JG, Verreault A. Unorthodox PCNA Binding by Chromatin Assembly Factor 1. Int J Mol Sci. 2022 Sep 21; 23(19).

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Iraqi M, Edri A, Greenshpan Y, Goldstein O, Ofir N, Bolel P, Abu Ahmad M, Zektser M, Campbell KS, Rouvio O, Gazit R, Porgador A. Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma. Int J Mol Sci. 2022 Apr 25; 23(9).

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Sverzhinsky A, Tomkinson AE, Pascal JM. Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure. 2022 03 03; 30(3):371-385.e5.

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Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE. Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation. J Mol Biol. 2020 12 04; 432(24):166698.

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Skolnik N. Treating Hypercholesterolemia in Older Adults-Reply. JAMA. 2019 08 20; 322(7):695-696.

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Kundu K, Ghosh S, Sarkar R, Edri A, Brusilovsky M, Gershoni-Yahalom O, Yossef R, Shemesh A, Soria JC, Lazar V, Joshua BZ, Campbell KS, Elkabets M, Porgador A. Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA. Cancer Immunol Res. 2019 07; 7(7):1120-1134.

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Skolnik N. Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults. JAMA. 2019 04 02; 321(13):1249-1250.

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Skolnik N. Inconsistent Hypertension Guidelines: We Need a Little Help Here. JAMA Intern Med. 2018 02 01; 178(2):297-298.

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