Interleukin-6

"Interleukin-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

Descriptor ID	D015850
MeSH Number(s)	D12.644.276.374.465.224 D12.776.467.374.465.202 D23.529.374.465.224
Concept/Terms	Interleukin-6 Interleukin-6 Interleukin 6 IL6 B-Cell Stimulatory Factor 2 B-Cell Stimulatory Factor-2 Differentiation Factor-2, B-Cell Differentiation Factor 2, B Cell B-Cell Differentiation Factor-2 B Cell Differentiation Factor 2 BSF-2 Hybridoma Growth Factor Growth Factor, Hybridoma IFN-beta 2 Plasmacytoma Growth Factor Growth Factor, Plasmacytoma Hepatocyte-Stimulating Factor Hepatocyte Stimulating Factor MGI-2 Myeloid Differentiation-Inducing Protein Differentiation-Inducing Protein, Myeloid Myeloid Differentiation Inducing Protein B-Cell Differentiation Factor B Cell Differentiation Factor Differentiation Factor, B-Cell Differentiation Factor, B Cell IL-6 Interferon beta-2 Interferon beta 2 beta-2, Interferon B Cell Stimulatory Factor-2 B Cell Stimulatory Factor 2

Below are MeSH descriptors whose meaning is more general than "Interleukin-6".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-6 [D12.644.276.374.465.224]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-6 [D12.776.467.374.465.202]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-6 [D23.529.374.465.224]

Below are MeSH descriptors whose meaning is related to "Interleukin-6".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-6" by people in this website by year, and whether "Interleukin-6" was a major or minor topic of these publications.

Bar chart showing 157 publications over 27 distinct years, with a maximum of 15 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	0	1	1
1999	1	0	1
2000	1	0	1
2002	3	3	6
2003	7	8	15
2004	0	4	4
2005	2	6	8
2006	4	5	9
2007	4	6	10
2008	6	8	14
2009	2	5	7
2010	0	4	4
2011	5	9	14
2012	4	8	12
2013	4	3	7
2014	4	3	7
2015	4	3	7
2016	0	4	4
2017	1	3	4
2018	1	0	1
2019	0	2	2
2020	1	4	5
2021	3	1	4
2022	1	4	5
2023	1	1	2
2024	1	1	2

Below are the most recent publications written about "Interleukin-6" by people in Profiles.

Assayag E, Gurt I, Cohen-Kfir E, Stokar J, Zwas DR, Dresner-Pollak R. Cardiac Left Ventricular miRNA-26a Is Downregulated in Ovariectomized Mice, Upregulated upon 17-Beta Estradiol Replacement, and Inversely Correlated with Collagen Type 1 Gene Expression. Int J Mol Sci. 2024 May 09; 25(10).

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Hirahara L, Kirino Y, Soejima Y, Iizuka Y, Yoshimi R, Fujieda Y, Atsumi T, Tono T, Kobayashi D, Meguro A, Takeuchi M, Sakamaki K, Takeno M, Mizuki N, Nakajima H. Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Beh?et disease: a prospective registry study. Front Immunol. 2024; 15:1354969.

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Nardella E, Biscetti F, Rando MM, Cecchini AL, Nicolazzi MA, Rossini E, Angelini F, Iezzi R, Eraso LH, Dimuzio PJ, Pitocco D, Massetti M, Gasbarrini A, Flex A. Development of a biomarker panel for assessing cardiovascular risk in diabetic patients with chronic limb-threatening ischemia (CLTI): a prospective study. Cardiovasc Diabetol. 2023 06 12; 22(1):136.

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Khan IA, Boyd BO, Chen AF, Cort?s-Penfield N, Myers TG, Brown TS, Suh GA, McGwin G, Ghanem ES, Fillingham YA. Utility of Diagnostic Tests Before Reimplantation in Patients Undergoing 2-Stage Revision Total Joint Arthroplasty: A Systematic Review and Meta-analysis. JBJS Rev. 2023 Mar 01; 11(3).

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Cafardi J, Miller C, Terebelo H, Tewell C, Benzaquen S, Park D, Egan P, Lebovic D, Pettit K, Whitman E, Tremblay D, Feld J, Buckley S, Roman-Torres K, Smith J, Craig A, Mascarenhas J. Efficacy and Safety of Pacritinib vs Placebo for Patients With Severe COVID-19: A Phase 2 Randomized Clinical Trial. JAMA Netw Open. 2022 12 01; 5(12):e2242918.

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Jengelley DHA, Wang M, Narasimhan A, Rupert JE, Young AR, Zhong X, Horan DJ, Robling AG, Koniaris LG, Zimmers TA. Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis. Cytokine. 2022 11; 159:155972.

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Pol T, Hijazi Z, Lindb?ck J, Oldgren J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Siegbahn A, Wallentin L. Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation. Cardiovasc Res. 2022 07 20; 118(9):2112-2123.

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Reyes M, Taghvaei M, Yu S, Sathe A, Collopy S, Prashant GN, Evans JJ, Karsy M. Targeted Therapy in the Management of Modern Craniopharyngiomas. Front Biosci (Landmark Ed). 2022 04 20; 27(4):136.

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Karamian BA, Levy HA, Boere P, Yalla GR, Canseco JA, Chang M, Divi SN, Fang T, Millhouse PW, Lendner M, Hilibrand AS, Vaccaro AR, Kepler CK, Markova DZ, Schroeder GD. Do Inflammatory Cytokines Affect Patient Outcomes After ACDF? Clin Spine Surg. 2022 05 01; 35(4):137-143.

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Deaner JD, Jaffe GJ, Keenan RT, Carnago L, Grewal DS. Anti-Interleukin-6 Antibodies for Autoimmune Retinopathy with Macular Edema. Ophthalmol Retina. 2022 01; 6(1):91-93.

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