Interleukin-12

"Interleukin-12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.

Descriptor ID	D018664
MeSH Number(s)	D12.644.276.374.465.512 D12.776.467.374.465.512 D23.529.374.465.512
Concept/Terms	Interleukin-12 Interleukin-12 Natural Killer Cell Stimulatory Factor IL-12 Cytotoxic Lymphocyte Maturation Factor IL 12 Edodekin Alfa IL-12 p70 Interleukin-12 p70 Interleukin 12 p70 p70, Interleukin-12 Interleukin 12 IL12

Below are MeSH descriptors whose meaning is more general than "Interleukin-12".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-12 [D12.644.276.374.465.512]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-12 [D12.776.467.374.465.512]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-12 [D23.529.374.465.512]

Below are MeSH descriptors whose meaning is related to "Interleukin-12".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-12".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-12" by people in this website by year, and whether "Interleukin-12" was a major or minor topic of these publications.

Bar chart showing 51 publications over 25 distinct years, with a maximum of 6 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	1	0	1
1998	2	0	2
1999	1	1	2
2000	2	0	2
2001	2	1	3
2002	2	1	3
2003	5	1	6
2004	3	1	4
2005	4	0	4
2006	0	3	3
2007	1	1	2
2008	0	4	4
2009	0	2	2
2010	0	1	1
2011	0	1	1
2012	0	1	1
2014	0	1	1
2017	1	0	1
2018	1	0	1
2020	0	1	1
2021	0	1	1
2022	0	2	2
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Interleukin-12" by people in Profiles.

Alvero AB, Fox A, Madina BR, Krady MM, Gogoi R, Chehade H, Nakaar V, Almassian B, Yarovinsky TO, Rutherford T, Mor G. Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory. Cancer Immunol Res. 2024 02 02; 12(2):261-274.

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Shirwaikar Thomas A, Lee SE, Shatila M, De Toni EN, T?r?k HP, Ben Khaled N, Powell N, Weight R, Faleck DM, Wang Y. IL12/23 Blockade for Refractory Immune-Mediated Colitis: 2-Center Experience. Am J Gastroenterol. 2023 09 01; 118(9):1679-1683.

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Palatnik-de-Sousa I, Wallace ZS, Cavalcante SC, Ribeiro MPF, Silva JABM, Cavalcante RC, Scheuermann RH, Palatnik-de-Sousa CB. A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron. Sci Rep. 2022 10 06; 12(1):16731.

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Rasouli J, Casella G, Zhang W, Xiao D, Kumar G, Fortina P, Zhang GX, Ciric B, Rostami A. Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype. Front Immunol. 2022; 13:912583.

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Lee SD, Shivashankar R, Quirk D, Zhang H, Telliez JB, Andrews J, Marren A, Mukherjee A, Loftus EV. Therapeutic Drug Monitoring for Current and Investigational Inflammatory Bowel Disease Treatments. J Clin Gastroenterol. 2021 03 01; 55(3):195-206.

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Shore ND, Morrow MP, McMullan T, Kraynyak KA, Sylvester A, Bhatt K, Cheung J, Boyer JD, Liu L, Sacchetta B, Rosencranz S, Heath EI, Nordquist L, Cheng HH, Tagawa ST, Appleman LJ, Tutrone R, Garcia JA, Whang YE, Kelly WK, Weiner DB, Bagarazzi ML, Skolnik JM. CD8+ T Cells Impact Rising PSA in Biochemically Relapsed Cancer Patients Using Immunotherapy Targeting Tumor-Associated Antigens. Mol Ther. 2020 05 06; 28(5):1238-1250.

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Oliveira AB, Bachi ALL, Ribeiro RT, Mello MT, Vaisberg M, Peres MFP. Exercise-Induced Change in Plasma IL-12p70 Is Linked to Migraine Prevention and Anxiolytic Effects in Treatment-Na?ve Women: A Randomized Controlled Trial. Neuroimmunomodulation. 2017; 24(6):293-299.

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Hern?ndez-Esquivel MA, P?rez-Torres A, Romero-Romero L, Reyes-Matute A, Loaiza B, Mellado-S?nchez G, Pav?n L, Medina-Rivero E, Pestell RG, P?rez-Tapia SM, Velasco-Vel?zquez MA. The dialyzable leukocyte extract TransferonTM inhibits tumor growth and brain metastasis in a murine model of prostate cancer. Biomed Pharmacother. 2018 May; 101:938-944.

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Thaker PH, Brady WE, Lankes HA, Odunsi K, Bradley WH, Moore KN, Muller CY, Anwer K, Schilder RJ, Alvarez RD, Fracasso PM. A phase I trial of intraperitoneal GEN-1, an IL-12 plasmid formulated with PEG-PEI-cholesterol lipopolymer, administered with pegylated liposomal doxorubicin in patients with recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancers: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017 11; 147(2):283-290.

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Cs?ka B, N?meth ZH, T?ro G, Koscs? B, K?kai E, Robson SC, Enjyoji K, Rolandelli RH, Erd?lyi K, Pacher P, Hask? G. CD39 improves survival in microbial sepsis by attenuating systemic inflammation. FASEB J. 2015 Jan; 29(1):25-36.

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