Interleukin-11

"Interleukin-11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.

Descriptor ID	D017370
MeSH Number(s)	D12.644.276.374.465.511 D12.776.467.374.465.511 D23.529.374.465.511
Concept/Terms	Interleukin-11 Interleukin-11 Interleukin 11 IL-11 IL11 Adipogenesis Inhibitory Factor Factor, Adipogenesis Inhibitory Inhibitory Factor, Adipogenesis

Below are MeSH descriptors whose meaning is more general than "Interleukin-11".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-11 [D12.644.276.374.465.511]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-11 [D12.776.467.374.465.511]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-11 [D23.529.374.465.511]

Below are MeSH descriptors whose meaning is related to "Interleukin-11".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-11".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-11" by people in this website by year, and whether "Interleukin-11" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
2002	2	0	2
2003	0	1	1
2015	3	0	3
2018	1	0	1
2019	1	0	1
2023	0	1	1

Below are the most recent publications written about "Interleukin-11" by people in Profiles.

Seyedsadr M, Wang Y, Elzoheiry M, Shree Gopal S, Jang S, Duran G, Chervoneva I, Kasimoglou E, Wrobel JA, Hwang D, Garifallou J, Zhang X, Khan TH, Lorenz U, Su M, Ting JP, Broux B, Rostami A, Miskin D, Markovic-Plese S. IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system. Proc Natl Acad Sci U S A. 2023 06 27; 120(26):e2221007120.

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Zhang X, Kiapour N, Kapoor S, Khan T, Thamilarasan M, Tao Y, Cohen S, Miller R, Sobel RA, Markovic-Plese S. IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. J Immunol. 2019 09 01; 203(5):1142-1150.

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Zhang X, Kiapour N, Kapoor S, Merrill JR, Xia Y, Ban W, Cohen SM, Midkiff BR, Jewells V, Shih YI, Markovic-Plese S. IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis. Clin Immunol. 2018 12; 197:45-53.

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Zhang X, Putoczki T, Markovic-Plese S. IL-11 in multiple sclerosis. Oncotarget. 2015 Oct 20; 6(32):32297-8.

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Zhang X, Wu H, Dobson JR, Browne G, Hong D, Akech J, Languino LR, Stein GS, Lian JB. Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGF?1. J Cell Biochem. 2015 Sep; 116(9):2098-108.

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Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, Drulovic J, Markovic-Plese S. IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. J Immunol. 2015 Jun 01; 194(11):5139-49.

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Filicko J, Lazarus HM, Flomenberg N. Mucosal injury in patients undergoing hematopoietic progenitor cell transplantation: new approaches to prophylaxis and treatment. Bone Marrow Transplant. 2003 Jan; 31(1):1-10.

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Kuenzler KA, Pearson PY, Schwartz MZ. IL-11 pretreatment reduces cell death after intestinal ischemia-reperfusion. J Surg Res. 2002 Dec; 108(2):268-72.

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Kuenzler KA, Pearson PY, Schwartz MZ. Interleukin-11 enhances intestinal absorptive function after ischemia-reperfusion injury. J Pediatr Surg. 2002 Mar; 37(3):457-9.

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Kiss C, Surrey S, Schreiber AD, Schwartz E, McKenzie SE. Human c-kit ligand (stem cell factor) induces platelet Fc receptor expression in megakaryoblastic cells. Exp Hematol. 1996 Aug; 24(10):1232-7.

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