CDC2 Protein Kinase

"CDC2 Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.

Descriptor ID	D016203
MeSH Number(s)	D08.811.913.696.620.682.700.646.500.500.250 D08.811.913.696.620.682.700.646.500.984.500 D12.644.360.250.067.249 D12.644.360.250.580.500 D12.776.167.200.067.249 D12.776.167.200.580.500 D12.776.476.250.067.249 D12.776.476.250.580.500 D12.776.744.360
Concept/Terms	CDC2 Protein Kinase CDC2 Protein Kinase Protein Kinase, CDC2 Cdk1 Protein Kinase Protein Kinase, Cdk1 cdk1 Kinase cdc2+ Protein Cyclin-Dependent Kinase 1 Cyclin Dependent Kinase 1 p34cdc2 Protein p34cdc2 Protein Protein p34cdc2 p34cdc2, Protein Histone Kinase p34(cdc2)

Below are MeSH descriptors whose meaning is more general than "CDC2 Protein Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.500.250]
Maturation-Promoting Factor [D08.811.913.696.620.682.700.646.500.984]
CDC2 Protein Kinase [D08.811.913.696.620.682.700.646.500.984.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
CDC2 Protein Kinase [D12.644.360.250.067.249]
Maturation-Promoting Factor [D12.644.360.250.580]
CDC2 Protein Kinase [D12.644.360.250.580.500]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
CDC2 Protein Kinase [D12.776.167.200.067.249]
Maturation-Promoting Factor [D12.776.167.200.580]
CDC2 Protein Kinase [D12.776.167.200.580.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
CDC2 Protein Kinase [D12.776.476.250.067.249]
Maturation-Promoting Factor [D12.776.476.250.580]
CDC2 Protein Kinase [D12.776.476.250.580.500]
Phosphoproteins [D12.776.744]
CDC2 Protein Kinase [D12.776.744.360]

Below are MeSH descriptors whose meaning is related to "CDC2 Protein Kinase".

Below are MeSH descriptors whose meaning is more specific than "CDC2 Protein Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CDC2 Protein Kinase" by people in this website by year, and whether "CDC2 Protein Kinase" was a major or minor topic of these publications.

Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 1993 and 1994 and 1995 and 2000 and 2003 and 2007 and 2008 and 2010 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1994	0	1	1
1995	1	0	1
2000	0	1	1
2003	1	0	1
2007	1	0	1
2008	0	1	1
2010	1	0	1
2015	0	1	1

Below are the most recent publications written about "CDC2 Protein Kinase" by people in Profiles.

Pai HC, Kumar S, Shen CC, Liou JP, Pan SL, Teng CM. MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27. PLoS One. 2015; 10(4):e0123819.

View in: PubMed
Shin ME, Skokotas A, Winter E. The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor. Mol Cell Biol. 2010 Jun; 30(12):2996-3003.

View in: PubMed
Rodriguez-Collazo P, Snyder SK, Chiffer RC, Bressler EA, Voss TC, Anderson EP, Genieser HG, Smith CL. cAMP signaling regulates histone H3 phosphorylation and mitotic entry through a disruption of G2 progression. Exp Cell Res. 2008 Sep 10; 314(15):2855-69.

View in: PubMed
Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan PJ, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar; 11(3):275-89.

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Manes T, Zheng DQ, Tognin S, Woodard AS, Marchisio PC, Languino LR. Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol. 2003 May 26; 161(4):817-26.

View in: PubMed
Bregman DB, Pestell RG, Kidd VJ. Cell cycle regulation and RNA polymerase II. Front Biosci. 2000 Feb 1; 5:D244-57.

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Wen SC, Ku DH, De Luca A, Claudio PP, Giordano A, Calabretta B. ets-2 regulates cdc2 kinase activity in mammalian cells: coordinated expression of cdc2 and cyclin A. Exp Cell Res. 1995 Mar; 217(1):8-14.

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Sala A, Nicolaides NC, Engelhard A, Bellon T, Lawe DC, Arnold A, Graña X, Giordano A, Calabretta B. Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res. 1994 Mar 15; 54(6):1402-6.

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Ku DH, Wen SC, Engelhard A, Nicolaides NC, Lipson KE, Marino TA, Calabretta B. c-myb transactivates cdc2 expression via Myb binding sites in the 5'-flanking region of the human cdc2 gene. J Biol Chem. 1993 Jan 25; 268(3):2255-9.

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Sala A, Calabretta B. Regulation of BALB/c 3T3 fibroblast proliferation by B-myb is accompanied by selective activation of cdc2 and cyclin D1 expression. Proc Natl Acad Sci U S A. 1992 Nov 1; 89(21):10415-9.

View in: PubMed

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