Receptors, Platelet-Derived Growth Factor
"Receptors, Platelet-Derived Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.
| Descriptor ID |
D017479
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.900 D12.776.543.750.630.625 D12.776.543.750.750.400.630
|
| Concept/Terms |
Receptors, Platelet-Derived Growth Factor- Receptors, Platelet-Derived Growth Factor
- Receptors, Platelet Derived Growth Factor
- Platelet-Derived Growth Factor Receptors
- Platelet Derived Growth Factor Receptors
- Receptors, PDGF
- PDGF Receptor
- Receptor, PDGF
- PDGF Receptors
- Platelet-Derived Growth Factor Receptor
- Platelet Derived Growth Factor Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Platelet-Derived Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Platelet-Derived Growth Factor".
This graph shows the total number of publications written about "Receptors, Platelet-Derived Growth Factor" by people in this website by year, and whether "Receptors, Platelet-Derived Growth Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptors, Platelet-Derived Growth Factor" by people in Profiles.
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Klinkhammer BM, Floege J, Boor P. PDGF in organ fibrosis. Mol Aspects Med. 2018 08; 62:44-62.
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Tsou PS, Talia NN, Pinney AJ, Kendzicky A, Piera-Velazquez S, Jimenez SA, Seibold JR, Phillips K, Koch AE. Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts. Arthritis Rheum. 2012 Jun; 64(6):1978-89.
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Lo HM, Wu MW, Pan SL, Peng CY, Wu PH, Wu WB. Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs. J Nutr Biochem. 2012 Jun; 23(6):667-78.
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Lewis NL, Lewis LD, Eder JP, Reddy NJ, Guo F, Pierce KJ, Olszanski AJ, Cohen RB. Phase I study of the safety, tolerability, and pharmacokinetics of oral CP-868,596, a highly specific platelet-derived growth factor receptor tyrosine kinase inhibitor in patients with advanced cancers. J Clin Oncol. 2009 Nov 1; 27(31):5262-9.
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Chew HK, Barlow WE, Albain K, Lew D, Gown A, Hayes DF, Gralow J, Hortobagyi GN, Livingston R. A phase II study of imatinib mesylate and capecitabine in metastatic breast cancer: Southwest Oncology Group Study 0338. Clin Breast Cancer. 2008 Dec; 8(6):511-5.
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Thomson S, Petti F, Sujka-Kwok I, Epstein D, Haley JD. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin Exp Metastasis. 2008; 25(8):843-54.
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Lewis NL. The platelet-derived growth factor receptor as a therapeutic target. Curr Oncol Rep. 2007 Mar; 9(2):89-95.
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Lasota J, Dansonka-Mieszkowska A, Sobin LH, Miettinen M. A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential. Lab Invest. 2004 Jul; 84(7):874-83.
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Miettinen M. New challenges in the identification of gastrointestinal stromal tumors and other possible KIT-driven tumors. Am J Clin Pathol. 2002 Feb; 117(2):183-5.
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Woodard AS, García-Cardeña G, Leong M, Madri JA, Sessa WC, Languino LR. The synergistic activity of alphavbeta3 integrin and PDGF receptor increases cell migration. J Cell Sci. 1998 Feb; 111 ( Pt 4):469-78.