"Receptor, Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
| Descriptor ID |
D011972
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.200 D12.776.543.750.630.484 D12.776.543.750.750.580.300
|
| Concept/Terms |
Receptor, Insulin- Receptor, Insulin
- Receptors, Insulin
- Insulin Receptors
- Insulin Receptor Protein-Tyrosine Kinase
- Insulin Receptor Protein Tyrosine Kinase
- Insulin Receptor
- Insulin-Dependent Tyrosine Protein Kinase
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Insulin".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Insulin".
This graph shows the total number of publications written about "Receptor, Insulin" by people in this website by year, and whether "Receptor, Insulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, Insulin" by people in Profiles.
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Morcavallo A, Buraschi S, Xu SQ, Belfiore A, Schaefer L, Iozzo RV, Morrione A. Decorin differentially modulates the activity of insulin receptor isoform A ligands. Matrix Biol. 2014 Apr; 35:82-90.
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Morcavallo A, Genua M, Palummo A, Kletvikova E, Jiracek J, Brzozowski AM, Iozzo RV, Belfiore A, Morrione A. Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A. J Biol Chem. 2012 Mar 30; 287(14):11422-36.
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Rozance PJ, Seedorf GJ, Brown A, Roe G, O'Meara MC, Gien J, Tang JR, Abman SH. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L860-71.
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Andersen AS, Palmqvist E, Bang S, Shaw AC, Hubalek F, Ribel U, Hoeg-Jensen T. Backbone cyclic insulin. J Pept Sci. 2010 Sep; 16(9):473-9.
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Sch?ffer L, Brand CL, Hansen BF, Ribel U, Shaw AC, Slaaby R, Sturis J. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun. 2008 Nov 14; 376(2):380-3.
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Slaaby R, Sch?ffer L, Lautrup-Larsen I, Andersen AS, Shaw AC, Mathiasen IS, Brandt J. Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J Biol Chem. 2006 Sep 08; 281(36):25869-74.
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Boden G, Chen X, Ruiz J, Heifets M, Morris M, Badosa F. Insulin receptor down-regulation and impaired antilipolytic action of insulin in diabetic patients after pancreas/kidney transplantation. J Clin Endocrinol Metab. 1994 Mar; 78(3):657-63.
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Krupinski J, Rajaram R, Lakonishok M, Benovic JL, Cerione RA. Insulin-dependent phosphorylation of GTP-binding proteins in phospholipid vesicles. J Biol Chem. 1988 Sep 05; 263(25):12333-41.
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Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. Endocr Rev. 1988 Feb; 9(1):38-56.