"Troponin C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. There are two troponin C subtypes: troponin C1 and C2. Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
| Descriptor ID |
D019209
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| MeSH Number(s) |
D05.500.945.900 D05.750.078.730.825.900 D12.776.157.125.900 D12.776.210.500.910.900 D12.776.220.525.825.900
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Troponin C".
Below are MeSH descriptors whose meaning is more specific than "Troponin C".
This graph shows the total number of publications written about "Troponin C" by people in this website by year, and whether "Troponin C" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Troponin C" by people in Profiles.
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Barrick SK, Greenberg L, Greenberg MJ. A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding. Mol Biol Cell. 2021 08 19; 32(18):1677-1689.
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Albury AN, Swindle N, Swartz DR, Tikunova SB. Effect of hypertrophic cardiomyopathy-linked troponin C mutations on the response of reconstituted thin filaments to calcium upon troponin I phosphorylation. Biochemistry. 2012 May 01; 51(17):3614-21.
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Lee RS, Tikunova SB, Kline KP, Zot HG, Hasbun JE, Minh NV, Swartz DR, Rall JA, Davis JP. Effect of Ca2+ binding properties of troponin C on rate of skeletal muscle force redevelopment. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1091-9.
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Tikunova SB, Liu B, Swindle N, Little SC, Gomes AV, Swartz DR, Davis JP. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 2010 Mar 09; 49(9):1975-84.
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Pearson DS, Swartz DR, Geeves MA. Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W. Biochemistry. 2008 Nov 18; 47(46):12146-58.
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Davis JP, Norman C, Kobayashi T, Solaro RJ, Swartz DR, Tikunova SB. Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J. 2007 May 01; 92(9):3195-206.
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Swartz DR, Yang Z, Sen A, Tikunova SB, Davis JP. Myofibrillar troponin exists in three states and there is signal transduction along skeletal myofibrillar thin filaments. J Mol Biol. 2006 Aug 18; 361(3):420-35.
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Ishikawa T, O-Uchi J, Mochizuki S, Kurihara S. Evaluation of the cross-bridge-dependent change in the Ca2+ affinity of troponin C in aequorin-injected ferret ventricular muscles. Cell Calcium. 2005 Feb; 37(2):153-62.